Hydrolysate of extruded soy proteins concentrate attenuates post myocardial infarction remodeling and improves heart health

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Research Paper 01/07/2019
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Hydrolysate of extruded soy proteins concentrate attenuates post myocardial infarction remodeling and improves heart health

Fatima Sultana, Nazir Ahmad, Farhan Saeed, Fatima Jalal, Zeeshan Hafeez
Int. J. Biosci.15( 1), 176-185, July 2019.
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Soybean is a good source of dietary proteins associated with numerous nutritional benefits and attenuates metabolic disorders like myocardial infarction (MI). Present study was aimed to explore the role of hydrolysate of extruded soy proteins concentrate (HESPC) intake in mitigation of MI. Isoprenaline induced MI rat groups (3-6) were fed on diet containing 5.07, 10.14, 15.21, 20.30 g proteins from Hydrolysates of extruded soy proteins concentrates (HESPC), respectively. Group 1 (non-induced MI) and group 2 (Isoprenaline induced MI) were fed on casein diet as control. Feed intake, body and heart weight, lactate dehydrogenase (LDH), creatine kinase-MB (CK), troponin, creatinine and urea, alanine aminotransferase (ALT), aspartate aminotransferase (AST), lipid profile, plasma proteins and homocysteine, cardiac and antioxidant enzymes and histopathology analysis were performed. The diet containing HESPC intake significantly changed body and heart weight. Lowest concentrations of LDH, CK-MB and troponin and highest concentration of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were observed in rats group fed on 20.30 g proteins. Blood cells count was significantly decreased on intake of HESPC in all groups. Plasma lipids, proteins, homocysteine, hepatic enzymes showed decreasing trend in rat groups with increasing percentage of HESPC in diet. Histopathological results showed healing of injured heart tissues was significant on HESPC intake. HESPC diet intake can improve biochemical parameters and cardiac tissues health.


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