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In-vivo biological investigations of methanolic extract of Himalrandia tetrasperma in animal model

By: Yaqoob ur Rehman, Bashir Ahmad, Mushtaq Ahmad, Saad Ahmad Khan, Muhammad Idrees, Shafaatullah, Umar Rehman, Farah Gul

Key Words: Himalrandia tetrasperma, Anti-inflammatory, Antipyretic, Antinociceptive, Acute toxicity

Int. J. Biosci. 16(3), 579-588, March 2020.

DOI: http://dx.doi.org/10.12692/ijb/16.3.579-588

Certification: ijb 2020 0012 [Generate Certificate]

Abstract

The study in reference was planned to evaluate the anti-inflammatory, antipyretic and antinociceptive activities of methanolic extract of Himalrandia tetrasperma (MEHT), as well as acute toxicity. Anti-inflammatory, antipyretic, antinociceptive and acute toxicity activities were evaluated using mice animal model. Anti-inflammatory activity was investigated using carrageenan-induced edema model of inflammation. Brewer, s yeast induced pyrexia method was employed to evaluate the antipyretic activity. To assess the antinociceptive property of extract two models were employed, acetic acid-induced writhing model and hot plate model. Acute toxicity was conducted with the help of well-established method. The extract showed significant (p < 0.01) anti-inflammatory effect. The extract exhibited prominent (p < 0.01) antipyretic activity. It also evoked substantial (p < 0.01) anti-nociceptive activity (both peripheral and central analgesia). Acute toxicity data revealed that the extract was non-toxic up to a dose of 1500 mg/kg. From these findings it has been found that MEHT could be used to develop a natural drug to cure these ailments.

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In-vivo biological investigations of methanolic extract of Himalrandia tetrasperma in animal model

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Yaqoob ur Rehman, Bashir Ahmad, Mushtaq Ahmad, Saad Ahmad Khan, Muhammad Idrees, Shafaatullah, Umar Rehman, Farah Gul.
In-vivo biological investigations of methanolic extract of Himalrandia tetrasperma in animal model.
Int. J. Biosci. 16(3), 579-588, March 2020.
https://innspub.net/ijb/vivo-biological-investigations-methanolic-extract-himalrandia-tetrasperma-animal-model/
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