Increased interleukin-1 beta is associated with high fasting glucose in obese men
Paper Details
Increased interleukin-1 beta is associated with high fasting glucose in obese men
Abstract
Interleukin-1 beat, a proinflammatory cytokine, plays important roles in systemic inflammation. The aims of present study were 1) to compare serum IL-1b between obese and none-obese me, 2) to determine serum IL-1b in relation to fasting glucose, insulin and beta-cell function in obese men. For this purpose, Venous blood samples were obtained after a overnight fast in order to measuring Il-1b, insulin, glucose in sedentary obese (30 ≤ BMI ≤ 36, n = 41) and none-obese (20 ≤ BMI ≤ 25, n = 36) men matched for age (370 ± 5, aged). Anthropometrical indexes were also monitored in two groups. Beta cell-function (HOMA-BF) was calculated by fasting insulin and glucose. Statistical analysis was performed by Independent sample T-test and Spearman rank correlation method. P value of <0.05 was accepted as significant. Serum IL-1b and glucose concentrations were significantly higher in obese men when compared with none-obese subjects (p < 0.05). Beat-cell function in obese men was lower than none-obese men (p < 0.05). IL-1b correlated negatively with the insulin and beta-cell function and positively with fasting glucose in obese men (p < 0.05). Based on this data, it was concluded that obesity is associated with systemic inflammation and Measurement of inflammatory indices may be represented glucose homeostasis in this population.
Bendtzen K, Mandrup-Poulsen T, Nerup J. 1986. Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans. Science 232, 1545 – 7.
Dasu MR, Devaraj S, Jialal I. 2007. High glucose induces IL-1beta expression in human monocytes: mechanistic insights. Am J Physiol Endocrinol Metab 293(1), 337-46.
Dinarello CA. 2009. Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 27, 519-50.
Ehses JA, Lacraz G, Giroix MH, Schmidlin F, Coulaud J, Kassis N et al. 2009. IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat. Proc Natl Acad Sci USA 106(33), 13998-4003.
Eizirik DL. 1988. Interleukin-1 induced impairment in pancreatic islet oxidative metabolism of glucose is potentiated by tumor necrosis factor . Acta Endocrinol (Copenh) 119, 321-5.
Juge-Aubry CE, Somm E, Chicheportiche R. 2004. Regulatory effects of interleukin (IL)-1, interferon-beta, and IL-4 on the production of IL-1 receptor antagonist by human adipose tissue. J Clin Endocrinol Metab 89, 2652–2658.
Kathrin M, Gitanjali D, Desiree M. 2009. Interleukin-1 beta targeted therapy for type 2 diabetes. Expert Opin. Biol. Ther 9(9), 1177-1188.
Lagathu C, Yvan-Charvet L, Bastard JP, Maachi M, Quignard-Boulangé A, Capeau A ET AL. 2006. Long-term treatment with interleukin-1β induces insulin resistance in murine and human adipocytes. Diabetologia 49(9), 2162-2173.
Maedler K, Dharmadhikari G, Schumann DM, Størling J. 2009. Interleukin-1 beta targeted therapy for type 2 diabetes. Expert Opin Biol Ther 9(9), 1177-88.
Manica-Cattani MF, Bittencourt L, Rocha MI, Algarve TD, Bodanese LC, Rech R et al. 2010. Association between interleukin-1 beta polymorphism (+3953) and obesity. Mol Cell Endocrinol 314(1), 84-9.
Meier CA, Thalmann S. 2007. White adipose tissue, inflammation and atherosclerosis. Bull Acad Natl Med 191(4-5), 897-908.
Osborn O, Brownell SE, Sanchez-Alavez M, Salomon D, Gram H, Bartfai T. 2008. Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity. Cytokine 44(1), 141-8.
Pukel C, Baquerizo H, Rabinovitch A . 1988. Destruction of rat islet cell monolayers by cytokines. Synergistic interactions of interferon-gamma, tumor necrosis factor ,lymphotoxin, and interleukin 1. Diabetes 37, 133-6.
Samaras K, Botelho NK, Chisholm DJ, Lord RV. 2010. Subcutaneous and visceral adipose tissue gene expression of serum adipokines that predict type 2 diabetes. Obesity (Silver Spring) 18(5), 884-9.
Takizawa H. 1998. Cytokines/chemokines and adhesion molecules in local inflammatory responses of the lung. Drug News Perspect 11(10), 611-9.
Um JY, Chung HS, Song MY, Shin HD, Kim HM. 2004. Association of interleukin-1beta gene polymorphism with body mass index in women. Clin Chem 50, 647–650.
Vincent JA, Mohr S. 2007. Inhibition of caspase-1/interleukin-1beta signaling prevents degeneration of retinal capillaries in diabetes and galactosemia. Diabetes 56(1), 224-30.
Eizadi Mojtaba, Khorshidi Davood, Seyedhoseini MohammadAli, Dooaly Hussein, 2011. Increased interleukin-1 beta is associated with high fasting glucose in obese men. Int. J. Biosci., 1(6), 141-146.
Copyright © 2011 by the Authors. This article is an open access article and distributed under the terms and conditions of the Creative Commons Attribution 4.0 (CC BY 4.0) license.