Phytochemical profiling, antioxidant and anticancer activity of seeds extracts of Syzygium cumini (L.)

Paper Details

Research Paper 06/07/2024
Views (704)
current_issue_feature_image
publication_file

Phytochemical profiling, antioxidant and anticancer activity of seeds extracts of Syzygium cumini (L.)

G. Rajeswari, S. Parvathi, S. Palanivel
J. Biodiv. & Environ. Sci. 25(1), 77-85, July 2024.
Copyright Statement: Copyright 2024; The Author(s).
License: CC BY-NC 4.0

Abstract

Syzygium cumini (L.) is a common plant and known for various medicinal properties. The study was conducted to investigate the phytochemical profiling, antioxidant and anticancer activity from the seeds of Syzygium cumini. Ethanol was prepared from seed of Syzygium cumini used for phytochemical analysis. The qualitative phytochemical screening of the ethanolic extract revealed the presence of alkaloids, flavonoids, tannins, terpenoids, saponins, phenols and carbohydrates. The quantitative analysis proved the presence of total flavonoids, phenols analysed by standard methods. The present findings clearly demonstrated that Syzygium cumini was an effective antioxidant in various studies like vitamin C, vitamin E and in vitro antioxidant assays including DPPH, reducing rower assay and performed by standard protocols. The anticancer activity can be detected by using colon cancer (cell line HP 29). It can be done in ethanol extract of Syzygium cumini plant seeds. Therefore, the study indicates that the Syzygium cumini ethanolic extract has higher antioxidant and anticancer activity.

Abd El-Moneim MR, Afify Sayed A, Fayed Emad A, Shalaby Hany A, El-Shemy H. 2011. Potent anticancer and antioxidant activities. Pharmacogenesis Magazine 5(7), 948-956.

Adelia FC, Marcella C, Mercadante Z. 2011. Identification of bioactive compounds from Jambolao (Syzygium cumini) and antioxidant capacity evaluation in different pH conditions. Food Chemistry 126(4), 1571-1578. DOI: 10.1016/j.foodchem.2010.12.007.

Alikatte KL, Akondi BR, Yerragunta VG, Veerareddy PR, Palle S. 2012. Antiamnesic activity of Syzygium cumini against copolamine induced spatial memory impairments in rats. Brain and Development 34(10), 844-851.

Ayyanar M, Subash-Babu P. 2012. Syzygium cumini (L.) Skeels: A review of its phytochemical constituents and traditional uses. Asian Pacific Journal of Tropical Biomedicine 2, 240-246.

Banerjee A, Dasgupta N. 2005. In vitro study of antioxidant activity of Syzygium cumini fruit. Food Chemistry 90(4), 727-731.

Banerjee J, Narendhira Kannan RT. 2011. Biosynthesis of silver nanoparticles from Syzygium cumini (L.) seed extract and evaluation of their in vitro antioxidant activities. Digest Journal of Nanomaterials and Biostructures 6(3), 961-968.

Bitencourt PE, Ferreira LM, Cargnelutti LO, Denardi L, Boligon A, Fleck M, Moretto MB. 2016. A new biodegradable polymeric nanoparticle formulation containing Syzygium cumini: phytochemical profile, antioxidant and antifungal activity and in vivo toxicity. Industrial Crops and Products 83, 400-407.

Brandão TS, Sena ARD, Teshima E, David JM, Assis SA. 2011. Changes in enzymes, phenolic compounds, tannins, and vitamin C in various stages of Jambolan (Syzygium cumini (Lamark)) development. Food Science and Technology 31, 849-855.

De Castro ML, Priego-Capote F. 2010. Soxhlet extraction: past and present panacea. Journal of Chromatography 1217(16), 2383-2389.

El-Nashar HA, Eldehna WM, Al-Rashood ST, Alharbi A, Eskandrani RO, Aly SH. 2021. GC/MS analysis of essential oil and enzyme inhibitory activities of Syzygium cumini (Pamposia) grown in Egypt: chemical characterization and molecular docking studies. Molecules 26(22), 6984.

Ferreira de Oliveira G, Jacometti NA, Furtado CF. 2007. Antimicrobial activity of Syzygium cumini (Myrtaceae) leaves extract. Pharmacogenesis Magazine 38, 381-384.

Greenwood D. 1989. Antibiotic sensitivity testing. In: Antimicrobial Chemotherapy. Oxford University, Oxford, p.91-100.

Gupta OP, Sing S, Bani S, Sharma N, Malhotra S, Gupta BD. 2000. Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase. Phytomedicine 7, 21-24.

Haroon R, Jelani S, Ahmed D, Arshad FK. 2015. Comparative analysis of radical scavenging and antioxidant profiles of bark, leaves and seeds of Syzygium cumini (Indian Blackberry). International Journal of Research – Granthaalayah 3(5), 13-26.

Hiroshi U, Chikako Y, Masatoshi Y. 2002. Luteolin as anti-inflammatory and anti-allergic constituent of Perilla fructens. Biol Pharm Bull 25, 1197-1202.

Kabra S, Patel S. 2018. Total phenolics & flavonoid content of the leaves of Carica papaya & Syzygium cumini. World Journal of Pharmaceutical Research 7(14), 734-741.

Khoda virdipour A, Zarean R, Safara lizadeh R. 2021. Evaluation of the anticancer effect of Syzygium cumini ethanolic extract on HT-29 colorectal cell line. June 2021.

Li L, Mangali S, Kour N, Dasari D, Ghatage T, Sharma V, Bhat A. 2021. Syzygium cumini (jamun) fruit-extracted phytochemicals exert anti-proliferative effect on ovarian cancer cells. Journal of Cancer Research and Therapeutics 17(6), 1547-1551.

Muruganandan S, Pant S, Srinivasan K, Chandra S, Tandan SK, Lal J. 2002. Inhibitory role of Syzygium cumini on autacoid-induced inflammation in rats. Indian J Physiol Pharmacol 46, 482-486.

Neha A, Vibha R. 2013. GC-MS analysis of bioactive components in the ethanolic and methanolic extract of Syzygium cumini. International Journal of Pharma and Bio Sciences 4(4).

Ramos IL, Bandiola TMB. 2017. Phytochemical screening of Syzygium cumini (Myrtaceae) leaf extracts using different solvents of extraction. Der Pharmacia Letter 9(2), 74-78.

Ruan ZP, Zhang LL, Lin YM. 2008. Evaluation of the antioxidant activity of Syzygium cumini leaves. Molecules 13(10), 2545-2556.

Sagrawat H, Mann A, Kharya M. 2006. Pharmacological potential of Eugenia jambolana: a review. Pharmacogenesis Magazine 2, 96-104.

Senthilkumar M, Gowri M, Vadivel V. 2017. Phytochemical analysis of bioactive compounds of Syzygium cumini (L.) Skeels. World Journal of Pharmaceutical Research 6(7), 1361-1379.

Sharma S. 2012. A review on pharmacological activity of Syzygium cumini extracts using different solvent and their effective doses. International Research Journal of Pharmacy 3(12), 54.

Solai Prakash AK, Devaraj E. 2019. Cytotoxic potentials of Syzygium cumini methanolic seed kernel extract in human hepatoma HepG2 cells. Environmental Toxicology 34(12), 1313-1319.

Vaidya ADB, Devasagayam TPA. 2007. Current status of herbal drugs in India: an overview. J Clin Biochem Nutr 41(1), 1-11.

Related Articles

Agroforestry in woody-encroached Sub-Saharan savannas: Transforming ecological challenges into sustainable opportunities

Yao Anicet Gervais Kouamé, Pabo Quévin Oula, Kouamé Fulgence Koffi, Ollo Sib, Adama Bakayoko, Karidia Traoré, J. Biodiv. & Environ. Sci. 27(3), 10-22, September 2025.

Extreme rainfall variability and trends in the district of Ouedeme, municipality of Glazoue (Benin)

Koumassi Dègla Hervé, J. Biodiv. & Environ. Sci. 27(3), 1-9, September 2025.

Heterosis breeding, general and specific combining ability and stability studies in pearl millet: Current trends

Ram Avtar, Krishan Pal, Kavita Rani, Rohit Kumar Tiwari, Mahendra Kumar Yadav, J. Biodiv. & Environ. Sci. 27(2), 117-124, August 2025.

Combining ability, heterosis and stability for yield and fibre quality traits in cotton: Breeding approaches and future prospects

Rohit Kumar Tiwari, Krishan Pal, R. P. Saharan, Ram Avtar, Mahendra Kumar Yadav, J. Biodiv. & Environ. Sci. 27(2), 109-116, August 2025.

Bridging the COPD awareness gap in marginalized populations: Findings from a multicentre study in Khalilabad, Sant Kabir Nagar, Uttar Pradesh, India

Anupam Pati Tripathi, Jigyasa Pandey, Sakshi Singh, Smita Pathak, Dinesh Chaudhary, Alfiya Mashii, Farheen Fatima, J. Biodiv. & Environ. Sci. 27(2), 97-108, August 2025.

Antioxidant and anti-inflammatory activity of Pleurotus citrinopileatus Singer and Pleurotus sajor-caju (Fr.) Singer

P. Maheswari, P. Madhanraj, V. Ambikapathy, P. Prakash, A. Panneerselvam, J. Biodiv. & Environ. Sci. 27(2), 90-96, August 2025.

Mangrove abundance, diversity, and productivity in effluent-rich estuarine portion of Butuanon River, Mandaue City, Cebu

John Michael B. Genterolizo, Miguelito A. Ruelan, Laarlyn N. Abalos, Kathleen Kay M. Buendia, J. Biodiv. & Environ. Sci. 27(2), 77-89, August 2025.

Cytogenetic and pathological investigations in maize × teosinte hybrids: Chromosome behaviour, spore identification, and inheritance of maydis leaf blight resistance

Krishan Pal, Ravi Kishan Soni, Devraj, Rohit Kumar Tiwari, Ram Avtar, J. Biodiv. & Environ. Sci. 27(2), 70-76, August 2025.