Prevalence of obesity and its impact on female reproductive health outcomes in Al-Baha Region: A retrospective assessment
Paper Details
Prevalence of obesity and its impact on female reproductive health outcomes in Al-Baha Region: A retrospective assessment
Abstract
Obesity has severe reproductive implications depending on the amount and distribution of body fat. Epidemiological studies have shown that obesity leads to abnormalities in menstruation, infertility, miscarriage, poor pregnancy outcomes, reduced fetal well-being, and diabetes mellitus. No previous study has investigated the Prevalence of Obesity and Its Impact on Female Reproductive Health Outcomes in Al-Baha Region, Saudi Arabia yet. We investigated the retrospective cross sectional case series studies of various patients to see the correlation between obesity, metabolic hormones, and female reproductive disorders. Because of the potential benefits of weight management, lifestyle intervention programs should constitute the first-line treatment for women with reproductive disorders. This retrospective cross-sectional case series study included adult female patients (aged >10 years) with obesity-related reproductive disorders. We examined all patient databases that contained various reproductive disorders and pharmacotherapy prescribed for a definite diagnosis of infertility, abortion, ectopic pregnancy, cervical cancer, irregular menstruation, and other less commonly reported reproductive abnormalities. The study included 150 patients, with 87.9% being married and 12.1% being unmarried. Obesity was linked to infertility concerns in 36.6% (n=55) of 150 obese adults, followed by 20.6% (n=31) of patients with irregular menstrual cycles. The percentage of patients with PCODs associated with increasing obesity was 8.7% (n=13). The proportion of patients who had abortions was 8.7% (n=13). Obesity caused cervical cancer in a small number of patients (1.3%, n=2). Other reproductive complications were responsible for 44% of the cases. In addition, a statistically significant difference of 0.001 was found in the reproductive diagnosis Variations with different age groups. A statistically significant difference of 0.05 was found between the various treatment regimens prescribed based on age groups. The correlation between BMI and obesity outcome according to age groups was found to have a statistically significant difference of 0.05. Obesity has been linked to a variety of reproductive problems. For life-threatening reproductive disorders such as cervical cancer and other reproductive disorders, pharmacotherapeutic interventions are available. Furthermore, because of the potential benefits of weight management, lifestyle intervention programs should be the first-line treatment for infertile women. As a result, personalized therapeutic assistance in clinical care is intended to encourage weight loss in obese patients with infertility. This may also be beneficial during pregnancy, allowing for a more comfortable physiological delivery and healthy pregnancies. The primary limitations of this study are the lack of statistics explaining the prevalence of obesity and its impact on the female reproductive system in Saudi Arabia, as well as the lack of previous studies on the research topic in Saudi Arabia.
Althumiri NA, Basyouni MH, AlMousa N, AlJuwaysim MF, Almubark RA, BinDhim NF, Alkhamaali Z, Alqahtani SA. 2021. Obesity in Saudi Arabia in 2020. Prevalence, Distribution and Its Current Association with Various Health Conditions. Healthcare (Basel) 9(3), 311.
Aversa A, La Vignera S, Rago R, Gambineri A, Nappi RE, Calogero AE, Ferlin A. 2020. Fundamental Concepts and Novel Aspects of Polycystic Ovarian Syndrome: Expert Consensus Resolutions. Front Endocrinol (Lausanne) 11, 11:516.
Cena H, Chiovato L, Nappi RE. 2020. Obesity, Polycystic Ovary Syndrome, and Infertility: A New Avenue for GLP-1 Receptor Agonists. The Journal of Clinical Endocrinology and Metabolism 105(8), e2695-709.
Crujeiras AB, Casanueva FF. 2015. Obesity and the reproductive system disorders: epigenetics as a potential bridge. Human Reproduction Update 21(2), 249-261.
Dag ZO, Dilbaz B. 2015. Impact of obesity on infertility in Women. Journal of the Turkish German Gynecological Association 16(2), 111-117.
Deswal R, Narwal V, Dang A, Pundir CS. 2020. The Prevalence of Polycystic Ovary Syndrome: A Brief Systematic Review. Journal of Human Reproductive Sciences 13(4), 261-271.
Di Berardino C, Peserico A, Capacchietti G, Zappacosta A, Bernabò N, Russo V, Mauro A, El Khatib M, Gonnella F, Konstantinidou F, Stuppia L, Gatta V, Barboni B. 2022. High-Fat Diet and Female Fertility across Lifespan: A Comparative Lesson from Mammal Models. Nutrients 14(20), 4341.
Fallatah AM, AlNoury A, Fallatah EM, Nassibi KM, Babatin H, Alghamdi OA, Tarabaih BY, Abduljabbar HS. 2021. Obesity among Pregnant Women in Saudi Arabia: A Retrospective Single-Center Medical Record Review. Cureus 13(2), e13454.
Fruh SM. 2017. Obesity: Risk factors, complications, and strategies for sustainable long-term weight management. The Journal of the American Association of Nurse Practitioners 29(S1), S3-S14
Glastras SJ, Chen H, Pollock CA, Saad S. 2018. Maternal obesity increases the risk of metabolic disease and impacts renal health in offspring. Bioscience Reports 38(2), BSR20180050.
Hieronimus B, Ensenauer R. 2021. Influence of maternal and paternal pre-conception overweight/obesity on offspring outcomes and strategies for prevention. Journal of Clinical Nutrition 75(12), 1735-1744.
Itriyeva K. 2022. The effects of obesity on the menstrual cycle. Current Problems in Pediatric and Adolescent Health Care 52(8), 101241.
Lam BCC, Lim AYL, Chan SL, Yum MPS, Koh NSY, Finkelstein EA. 2023. The impact of obesity: a narrative review. Singapore Medical Journal 64(3), 163-171.
Lin X, Li H. 2021. Obesity: Epidemiology, Pathophysiology, and Therapeutics. Front Endocrinol (Lausanne) 12, 706978.
Medenica S, Spoltore ME, Ormazabal P, Marina LV, Sojat AS, Faggiano A, Gnessi L, Mazzilli R, Watanabe M. 2023. Female infertility in the era of obesity: The clash of two pandemics or inevitable consequence? Clinical Endocrinology 98(2), 141-152.
Nurul-Farehah S, Rohana AJ. 2020. Maternal obesity and its determinants: A neglected issue? Malaysian Family Physician 15(2), 34-42.
Reavey JJ, Walker C, Murray AA, Brito-Mutunayagam S, Sweeney S, Nicol M, Cambursano A, Critchley HOD, Maybin JA. 2021. Obesity is associated with heavy menstruation that may be due to delayed endometrial repair. Journal of Endocrinology 249(2), 71-82.
Reichetzeder C. 2021. Overweight and obesity in pregnancy: their impact on epigenetics. The European Journal of Clinical Nutrition 75(12), 1710-1722.
Riley L, Wertz M, McDowell I. 2018. Obesity in Pregnancy: Risks and Management. American Family Physician 97(9), 559-561.
Sadeghi HM, Adeli I, Calina D, Docea AO, Mousavi T, Daniali M, Nikfar S, Tsatsakis A, Abdollahi M. 2022. Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing. International Journal of Molecular Sciences 23(2), 583.
Schmandt RE, Iglesias DA, Co NN, Lu KH. 2021. Understanding obesity and endometrial cancer risk: opportunities for prevention. American Journal of Obstetrics and Gynecology 205(6), 518-525.
Silvestris E, Lovero D, Palmirotta R. 2019. Nutrition and Female Fertility: An Interdependent Correlation. Front Endocrinol (Lausanne) 10, 346.
Sun K, Xie Y, Zhao N, Li Z. 2019. A case-control study of the relationship between visceral fat and development of uterine fibroids. Experimental and Therapeutic Medicine 18(1), 404-410.
Tauqeer Z, Gomez G, Stanford FC. 2018. Obesity in Women: Insights for the Clinician. Journal of Women’s Health 27(4), 444-457
Tiwari A, Balasundaram P. 2023. Public Health Considerations Regarding Obesity. 2023 Mar 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing PMID, 34283488.
Weiss NS, Kostova E, Nahuis M, Mol BWJ, van der Veen F, van Wely M. 2019. Gonadotrophins for ovulation induction in women with polycystic ovary syndrome. Cochrane Database of Systematic Reviews 1(1), CD010290.
Yang Y, He Y, Zeng Q, Li S. 2014. Association of body size and body fat distribution with uterine fibroids among Chinese women. Journal of Women’s Health 23(7), 619-626.
Saba Beigh, Alanoud Jabbar, Sahar Ayedh, Shaima Mohamed, Nouf Fahad, Rabab Morsy Ahmed, Leila Abdallah Elawad Mohamed Nour, 2023. Prevalence of obesity and its impact on female reproductive health outcomes in Al-Baha Region: A retrospective assessment. Int. J. Biosci., 23(3), 75-86.
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