Review on phytochemical evaluation and extraction of Nigella sativa (Kalongi) with pharmacological and traditional applications

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Research Paper 01/03/2020
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Review on phytochemical evaluation and extraction of Nigella sativa (Kalongi) with pharmacological and traditional applications

Mehwish Qayyum, Kanwal Ashiq, Samreen Tanveer, Mayyda Asif Bajwa, Asma Shah Rukh, Nimra Jahangir, Maria Ishaq, Aqsa Rabbani, Maria Aslam, Taiba Majeed, Hiba Ashraf
Int. J. Biosci.16( 3), 231-241, March 2020.
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Abstract

Nigella sativa is an annual flowering plant and belonging to family Ranunculaceae. The plant is commonly grown and nurtured in India and Pakistan. In addition, Mediterranean countries have also been reported to cultivate the plant. The height of the herb is about 45 cm and length of the leaves is from 2.5 to 5.0 cm. The shape of the leaves is lanceolate and linear. The color of petals of the flower is pale blue and its seeds are externally black in color and internally white. The plant has been utilized conventionally as well as pharmacologically for treatment of various diseases, i.e. chest congestion, hypertension, obesity, piles, bacterial infections, fever, jaundice, fungal infections, cancers, inflammation, oxidative stress, paralysis, fatigue etc. Seeds are consumed in a variety of ways interchangeably i.e. as condiment and spice. Nigella sativa is enriched with various significant phytochemicals, including: glycoscides, carbohydrates, alkaloids, tannins, alkaloids, volatile oil, terpenoids, and flavonoids, steroids resinous and phenolic compounds. The other most important chemical constituents are thymol, carvone, thymoquinone, nigellicimine, nigellicine, dithymoquinone and thymohydroquinone. The medicinal herb contains relatively good amounts of copper (Cu), iron (Fe), potassium (K), phosphorous (P), calcium (Ca) and zinc (Zn). Natural products have been used as a major source of treatment and diet for the provision of essential nutrition and health for both animal and humans. All these aspects catch the attention of researchers to approach the utility, efficiency and potency of Nigella sativa.

VIEWS 16

Abbas RZ, Iqbal Z, Khan A, Sindhu ZU, Khan JA, Khan MN, Raza A. 2012. Options for integrated strategies for the control of avian coccidiosis. International Journal of Agriculture and Biology 14, 1014-20.

Abdel Azeiz AZ, Saad AH, Darweesh MF. 2013. Efficacy of thymoquinone against vaginal candidiasis in prednisolone-induced immunosuppressed mice.  The Journal of American Science 9, 155–159.

Agrawal R, Kharya MD, Shrivastava R. 1979. Anti-microbial and anthelmintic activities of the essential oil of Nigella sativa Linn. Indian Journal of Experimental Biology 17, 1264–1265.

Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, Damanhouri ZA, Anwar F. 2013. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pacific Journal of Tropical Biomedicine 3, 337-52. https://doi.org/10.1016/S2221-1691(13)60075-1

Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, Damanhouri ZA, Anwar F. 2013. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pacific Journal of Tropical Biomedicine 3, 337-52. https://doi.org/10.1016/S2221-1691(13)60075-1

Aitzetmüller K, Werner G, Ivanov SA. 1997. Seed oils of Nigella species and of closely related genera. Oleagineux Corps Gras Lipides 4, 385-388.

Al-Ghamdi MS. 2001. The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa. Journal of Ethnopharmacology 76, 45-8. https://doi.org/10.1016/S0378-8741(01)00216-1

Ali BH, Blunden G. 2003. Pharmacological and toxicological properties of Nigella sativa. Phytotherapy Research 17, 299-305.

Atta-ur-Rahman E, Malik S, Sadiq S, Choudhary M, Ni Z, Clardy J, Taufiq-Ur-Rahman SJ, Hasan SS, Choudhary MI. 1995. Nigellidine-a new indazole alkaloid from the seed of Nigella sativa. Tetrahedron Letters 36, 1993-1996. https://doi.org/10.1016/0040-4039(95)00210-4

Bamosa AO, Kaatabi H, Lebdaa FM, Elq AM, Al-Sultanb A. 2010. Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus. Indian Journal of Physiology Pharmacology 54, 344-54.

Bamosa AO, Kaatabi H, Lebdaa FM, Elq AM, Al-Sultanb A. 2010. Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus. Indian Journal of Physiology and Pharmacology 54, 344-54.

Beckstrom-Sternberg SM, Duke JA. 1994. Potential for synergistic action of phytochemicals in spices. In Spices Herbs and Edible Fungi. 201–223.

Boskabady MH, Mohsenpoor N, Takaloo L. 2010. Anti-asthmatic effect of Nigella sativa in airways of asthmatic patients.Phytomedicine 17, 707-713. https://doi.org/10.1016/j.phymed.2010.01.002

Burits M, Bucar F. 2000.Anti-oxidant activity of Nigella sativa essential oil. Phyto Therapy Research 14, 323-328.

Chaieb K, Kouidhi B, Jrah H, Mahdouani K, Bakhrouf A. 2011. Anti-bacterial activity of Thymoquinone, an active principle of Nigella sativa and its potency to prevent bacterial bio film formation.BMC Complementary and Alternative Medicine 11, 29. https://doi.org/10.1186/1472-6882-11-29

Cheikh-Rouhou S, Besbes S, Hentati B, Blecker C, Deroanne C, Attia H. 2007. Nigella sativa L.: Chemical composition and physicochemical characteristics of lipid fraction. Food chemistry 101, 673-81. https://doi.org/10.1016/j.foodchem.2006.02.022

Chopra RN, Chopra SL, Handa KL, Kapur LD. 1958. Indigenous Drugs of India, UNDhur and Sons Pvt Ltd, Calcutta.

Daba MH, Abdel-Rahman MS. 1998. Hepatoprotective activity of thymoquinone in isolated rat hepatocytes. Toxicology letters 16, 23-9. https://doi.org/10.1016/S0378-4274(98)00012-

El Daly ES. 1998. Protective effect of cysteine and vitamin E, Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in rats. Journal de Pharmacie de Belgique 53, 87.

El Gazzar M, El Mezayen R, Marecki JC, Nicolls MR, Canastar A, Dreskin SC. 2006.  Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation. International immunopharmacology 6, 1135-42. https://doi.org/10.1016/j.intimp.2006.02.004

El Tahir KE, Ashour MM, Al-Harbi MM. 1993. The respiratory effects of the volatile oil of the black seed (Nigella sativa) in guinea-pigs: elucidation of the mechanism (s) of action. General Pharmacology: The Vascular System 24, 1115-22.

El-Dakhakhny M, Barakat M, AbdEl-Halim M, Aly SM. 2000a. Effect of Nigella sativa oil on gastric secretion and ethanol induced ulcer in rats. Journal of Ethnopharmacology 72, 299–304.

El-Dakhakhny M. 1963. Studies on the chemical constituents of Egyptian Nigella sativa L seeds. Planta Medica 11, 465–470.

El-Kadi A, Kandil O. 1887. The black seed (Nigella sative) and immunity: its effect on human T cell subset. In Fed. Proc 46, 222.

Enomoto S, Asano R, Iwahori Y, Narui T, Okada Y, Singab AN, Okuyama T. 2001. Hematological studies on black cumin oil from the seeds of Nigella sativa L. Biological and Pharmaceutical Bulletin 24, 307-10.

Gali‐Muhtasib H, Ocker M, Kuester D, Krueger S, El‐Hajj Z, Diestel A, Evert M, El‐Najjar N, Peters B, Jurjus A, Roessner A. 2008. Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models. Journal of Cellular and Molecular Medicine 12, 330-42.

Gilani AUH, JabeenQ, Khan MAU. 2004. A review of medicinal uses and pharmacological activities of Nigella sativa. Pakistan Journal of Biological Sciences 7, 441-51.

Goreja WG. 2003. Black seed: nature’s miracle remedy. Karger Publishers.

Hailat N, Bataineh Z, Lafi S, Raweily E, Aqel M, Al-Katib M, Hanash S. 1995. Effect of Nigella sativa volatile oil on Jurkat T cell leukemia polypeptides. International Journal of Pharmacognosy 33, 16-20. https://doi.org/10.3109/13880209509088141

Halawani E. 2009. Antibacterial activity of thymoquinone and thymohydroquinone of Nigella sativa L. and their interaction with some antibiotics. Advances in Biological Research 3, 148-52.

Hanafy MSM, Hatem ME. 1991. Studies on the anti-microbial activity of Nigella sativa seed (black cumin). Journal of Ethnopharmacology 34, 275-278. https://doi.org/10.1016/0378-8741(91)90047-H

Haq A, Lobo PI, Al-Tufail M, Rama NR, Al-Sedairy ST. 1999. Immunomodulatory effect of Nigella sativa proteins fractionated by ion exchange chromatography. International Journal of Immunopharmacology 21, 283-95. https://doi.org/10.1016/S0192-0561(99)00010-7

Hosseinzadeh H, Taiari S, Nassiri-Asl  M. 2012.  Effect of thymoquinone, a constituent of Nigella sativa L. on ischemia-reperfusion in rat skeletal muscle. Naunyn-Schmiedeberg’s Archives of Pharmacology 385, 503–508.

Hosseinzadeh H, Parvardeh S, Nassiri-Asl M, Mansouri MT. 2005. Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. Medical Science Monitor 11, BR106-10.

Hosseinzadeh H, Parvardeh S. 2004. Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice. Phytomedicine 11, 56–64. https://doi.org/10.1078/0944-7113-00376

Houghton PJ, Zarka R, Heras B, Hoult JRS. 1995. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Plantamedica 61, 33-36. https://doi.org/10.1111/j.1582-4934.2007.00095.x

Javed S, Shahid AA, Haider MS, Umeera A, Ahmad R, Mushtaq S. 2012. Nutritional, phytochemical potential and pharmacological evaluation of Nigella Sativa (Kalonji) and Trachyspermum Ammi (Ajwain). Journal of Medicinal Plants Research 6, 768-75. http://dx.doi.org/10.5897/JMPR11.1341

Khader M, Bresgen N, Eckl PM. 2009. In vitro toxicological properties of thymoquinone. Food and Chemical Toxicology 47,129-133.

Khan MA. 1999. Chemical composition and medicinal properties of Nigella sativa Linn. Inflammopharmacology 7, 15-35. https://doi.org/10.1007/s10787-999-0023-y

Khan MA. 1999. Chemical composition and medicinal properties of Nigella sativa Linn. Inflammopharmacology 7, 15-35. https://doi.org/10.1007/s10787-999-0023-y

Kouidhi B, Zmantar T, Jrah H, Souiden Y, Chaieb K, Mahdouani K, Bakhrouf A. 2011. Antibacterial and resistance-modifying activities of thymoquinone against oral pathogens. Annals of Clinical Microbiology and Antimicrobials 1, 29.

Mahmoud MR, El-Abhar HS, Saleh S. 2002. The effect of Nigella sativa oil against the liver damage induced by Schistosoma mansoni infection in mice. Journal of Ethnopharmacology 79, 1-1. https://doi.org/10.1016/S0378-8741(01)00310-5

Malika NO, Mohamed F, Chakib EA. 2004. Antimicrobial activities of natural honey from aromatic and medicinal plants on antibio-resistant strains of bacteria. International Journal of Agriculture and Biology 6, 289-93.

MathurM L, Gaur J, Sharma R, Haldiya KR. 2011. Anti-diabetic properties of a spice plant Nigella sativa. Journal of Endocrinology and Metabolism 1, 1-8.

Parhizkar S, Latiff LA, Parsa A. 2016.Effect of Nigella sativa on reproductive system in experimental menopause rat model. Avicenna Journal of Phytomedicine 6, 95.

Parvardeh S, Nassiri-Asl M, Mansouri MT, Hosseinzadeh H. 2005. Study on the anticonvulsant activity of thymoquinone, the major constituent of Nigella sativa L. seeds, through intracerebroventricular injection. Journal of Medicinal Plants 2, 45-52.

Qidwai W, Hamza HB, Qureshi R, Gilani A. 2009. Effectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trial. The Journal of Alternative and Complementary Medicine 5, 639-44.

Randhawa MA, Al-Ghamdi MS. 2002. A review of the pharmaco-therapeutic effects of Nigella sativa. Pakistan Journal of Medical Research 41, 77-83.

Randhawa MA, Alghamdi MS. 2011. Anti-cancer activity of Nigella sativa (blackseed)—a review.The American Journal of Chinese Medicine 39, 1075-1091.

Razavi BM, Hosseinzadeh H. 2014. A review of the effects of Nigella sativa L. And its constituent, thymoquinone, in metabolic yndrome. Journal of Endocrinological Investigation 37, 1031-1040. https://doi.org/10.1007/s40618-014-0150-1

Rifat-uz-Zaman MS, Khan MS. 2004. Gastroprotective and anti-secretory effect of Nigella sativa seed and its extracts in indomethacin-treated rats. Pakistan Journal of Biological Sciences 7, 995-1000.

Salem ML, Hossain MS. 2000. Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection. International Journal of Immunopharmacology 22, 729-40. https://doi.org/10.1016/S0192-0561(00)00036-9

Salem ML. 2005. Immunomodulatory and therapeutic properties of the Nigella sativaL seed. International Immunopharmacology 5, 1749-1770.

Satyavati GV, Raina MK, Sharma M. 1987. Medicinal plants of India. Indian Council of Medical Research 474-475.

Shafi G, Munshi A, Hasan TN, Alshatwi AA, Jyothy A, Lei DK. 2009. Induction of apoptosis in HeLa cells by chloroform fraction of seed extracts of Nigella sativa. Cancer Cell International 1, 29. https://doi.org/10.1186/1475-2867-9-29

Sofowora A. 1993. Medicinal plants and traditional medicine in Africa. Ibadan. Spectrum Ltd. 152-161.

Staphylakis PK, Gegiou D. 1986. The sterols of Nigella sativa seed oil. Phytochemistry 25, 761–763. https://doi.org/10.1016/0031-9422(86)88046-3

Tembhurne SV, Feroz S, More BH, Sakarkar DM. 2014. A review on therapeutic potential of Nigella sativa (kalonji) seeds. Journal of Medicinal Plants Research 8, 167-77.