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Study of hematological and biochemical effects of sub-lethel doses of the blue green alga Lyngbya aestuarii

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Research Paper 01/02/2020
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Study of hematological and biochemical effects of sub-lethel doses of the blue green alga Lyngbya aestuarii

E.Y.A. Al-Sultan, F. S. Kataa, A.M. Eassa
Int. J. Biosci.16( 2), 103-123, February 2020.
Certificate: IJB 2020 [Generate Certificate]
Key: Biochemical aspectsFemale miceHematological aspectsLyngbya aestuariiToxicity

Abstract

Cyanobacteria are photosynthetic prokaryotic organisms that colonize a wide variety of habitats. They are the source of more than 300 bioactive secondary compounds. Among those secondary metabolites, the cyanotoxins which have received most of the research attention therefore, the present work aimed to study the detrimental effects of methanolic extract of Lyngbya aestuariion on some physiological aspects in female mice. Hematological parameters were analyzed with automated Hematological analyzer while other biochemical parameters were achieved with commercial kits using spectrophotometer apparatus according to manufacture instructions. The present results showed a significant increase in the red blood corpuscles’ count in both low and high dose groups comparable with control group and there are a significant increase in both HGB and HCT in low dose group comparable with control. Also, there are significant increase in percentage of monocytes in high dose group comparable with control group. Liver enzymes showed significant differences in mice groups for AST only where the low dose treatment registered significant increase in concentrations comparable with control treatment. Concentration of both urea and creatinine showed significant increase in low dose group only comparable with control group which reflect kidney dysfunction. There are significant decreasing in concentration of HDL among mice groups comparable with control group. Finally, total protein concentrations showed significant increase in high dose treatment comparable with control treatment. In conclusion, the detrimental effect of the toxic extract of L. aestuarii was on kidney function.

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