Study of the lipid profile of malnourished people living with HIV monitored at the Notre Dame Apôtres Hospital in Sarh, CHAD

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Research Paper 14/12/2023
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Study of the lipid profile of malnourished people living with HIV monitored at the Notre Dame Apôtres Hospital in Sarh, CHAD

Isabelle Sacramento, Odile Soudonou, Pascaline B. Tiamou N'Koue, Chantal Hounkpatin, Alphonse Sezan, Jean Marc Atègbo
Int. J. Biosci. 23(6), 249-254, December 2023.
Copyright Statement: Copyright 2023; The Author(s).
License: CC BY-NC 4.0

Abstract

HIV/AIDS remains a major public health problem with a high morbidity and mortality rate. The nutritional status of infected persons is weakened for pathophysiological reasons related to the infection and because PLWHIV often have diets relatively low in energy, protein and other nutrients, which may affect the progression of the infection by weakening the immune system with the advent of opportunistic infections and metabolic abnormalities including dyslipidemias. The objective of the present study is to describe the lipid profile of people living with HIV malnuti followed at the NDA hospital in Sarh, Chad. It was a descriptive and analytical study. The study population consisted of people living with HIV followed up at the NDA hospital in Maïngara, Sarh. The lipid profile was assessed by the lipid balance performed in fasting patients. A total of 34 patients were included in the study. Women were predominant (74%). The average age was 43 ± 5 years. Total hypercholesterolemia was observed in 06 patients (17.65%), LDL hypercholesterolemia in 01 patient (2.94%) with pathological LDL hypocholesterolemia observed in 25 patients (73.53%), HDL hypocholesterolemia in 68 patients (27.87%) and hypertriglyceridemia in 44 patients (18.03%). Triglyceridemia to HDL cholesterol ratio was high in 05 patients (14.70%). Malnutrition was associated with dyslipidemia. The lipid profile of HIV infected patients in the present study is characterized by the presence of dyslipidemias promoted by malnutrition.

Abebe M, Kinde S, Belay G, Gebreegziabxier A, Challa F, Gebeyehu T, Nigussie P, Tegbaru B. 2014. Antiretroviral treatment associated hyperglycemia and dyslipidemia among HIV-infected patients at Burayu Health Center, Addis Ababa, Ethiopia: a cross-sectional comparative study. BMC Research Notes 7, 380.

Adane A, Desta K, Bezabih A, Gashaye A, Kassa D. 2012. HIV-associated anaemia before and after initiation of antiretroviral therapy at Art Centre of Minilik II Hospital, Addis Ababa, Ethiopia. Ethiopian medical journal 50, 13-21.

Adébayo A, Albert Comlan D, Angelo Cossi A, Jules G, Moutawakilou G, Armand W, Léopold C, Colette A, Djimon Marcel Z, François D. 2016. Lipid profile of people living with HIV under antiretroviral treatment followed at the Centre Hospitalier Universitaire Ouémé-Plateaux (CHU-O/P) of Porto-Novo, Benin; Int. J. Biol. Chem. Sci. 10(5), 2175-2182.

Al Anazi AR. 2009, Gastrointestinal opportunistic infections in human immunodeficiency virus disease. Saudi journal of gastroenterology: official journal of the Saudi Gastroenterology Association 15, 95-99.

Alcock NW. 1999. Laboratory Tests for Assessing Nutritional Status. In: Modern Nutrition in Health and Disease (Shils, M. E. et al. Eds): Williams & Wilkins.

Al-Dakkak I, Patel S, McCann E, Gadkari A, Prajapati G, Maiese EM. 2013. The impact of specific HIV treatment-related adverse events on adherence to antiretroviral therapy: a systematic review and meta-analysis. AIDS care 25, 400-414.

Alibhai A, Kipp W, Saunders LD, Senthilselvan A, Kaler A, Houston S, Konde-Lule J, Okech-Ojony J, Rubaale T. 2010. Gender-related mortality for HIV-infected patients on highly active antiretroviral therapy (HAART) in rural Uganda. International journal of women’s health 2, 45-52.

Allard JP, Aghdassi E, Chau J, Salit I, Walmsley S. 1998. Oxidative stress and plasma antioxidant micronutrients in humans with HIV infection. Am J Clin Nutr 67, 143-147.

Alliouch-kerboua A. 2019. HIV INFECTION, Faculty of Medicine of Annaba Department of Pharmacy 4 th Year of Pharmacy Immunology Module.

Anabwani G, Navario P, 2005, Nutrition and HIV/AIDS in sub-Saharan Africa: an overview. Nutrition 21, 96-99.

Dallongeville J. 2006. Lipoprotein metabolism Cah.Nutr.Diét. 41(1).

De Pee S, Semba RD. 2010. Role of nutrition in HIV infection: review of evidence for more effective programming in resource-limited settings. Food and nutrition bulletin 31, S313-344.

Edvard. 2016. Back To Physio: The blood pressure curve

Ellen G. Piwoz, Elizabeth A. Preble. 2001. HIV/AIDS and nutrition A review of the literature and recommendations for nutritional care and support in sub-Saharan Africa.

Fitch K, Grinspoon S. 2011. Nutritional and metabolic correlates of cardiovascular and bone disease in HIV-infected patients. Am J Clin Nutr; 94(6), 721S-8S.

Fresco C, Maggioni A. P, Signorini S, Merlini P. A, Mocarelli P, Fabbri G. 2002. Variation in lipoprotein elevels after myocardialin fraction and unstableangina : the LATENE trail ital Heart J. 3, 587-592.

International Labour Organization. 2015. Handbook on HIV and AIDS for labour inspectors.

Marcel DZ. 2016. generalities on HIV infection, internal medicine course, Faculty of Health Sciences, Cotonou, Benin; 27p.

MPS-Congo. USAID. FANTA III. FHI 360. 2016. Protocole National de Prise en Charge Nutritionnelle des Personnes Vivant avec le VIH: 96p.

Nabila R, Selma T. 2019. Analysis of some biochemical markers in patients with hypertension, 36p.

Ojong WE, Achidi EA, Apinjoh TO, Kamga H, Njunda A. 2016. A study of the effects of HIV infection and ART treatment on the serum lipid profile of HIV/AIDS patients attending the Nylon District Hospital, Douala, Cameroon. International Journal of Medical Science and Public Health 5(3), 534-538. 

Patricia F, Claire C. 2007. Risk factors for HIV/AIDS infection in women, 62p.

UNAIDS. 2014. Nutritional assessment, counseling and support for adolescents and adults living with HIV.

UNAIDS policy brief: latest statistics. 2020. URL: https://www.unaids.org/fr/resources/fact-sheet.

Sicotte. 2014. Malnutrition, HIV and antiretroviral treatment in resource-limited countries, Thesis presented to the Faculty of Graduate Studies for the degree of Doctor of Public Health, Epidemiology option Université de Montréal, 231p.

Véronique AF, Charlotte C, Dr Benoit V. 2017. Human immunodeficiency virus (HIV).

WHO. 2003. Nutrient needs of people living with HIV/AIDS Report of a technical consultation 16p.

WREN media Fressingfield. 2007. Nutrition and HIV/AIDS, 07/6, 43p

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