Synthesis, characterization and biological activities of cephalosporin metals complexes

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Research Paper 01/11/2016
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Synthesis, characterization and biological activities of cephalosporin metals complexes

Rehmat Zaman, Wajid Rehman, Mukhtiar Hassan, Muhammad Mumtaz khan, Zeeshan Anjum, Syed Asad Hussain Shah, Syed Rizwan Abbas
Int. J. Biosci.9( 5), 163-172, November 2016.
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Abstract

Cephalosporin is widely used group prescribed as broad-spectrum antibiotic, containing β-lactam ring. Numerous different bacteriological pathogens are now resistant against cephalosporin due to over use. Subsequently it is necessary to synthesize new derivatives to enhance biological activity against pathogens. In current study cephalosporin were reacted with essential trace elements to synthesize respective metal complexes. The novel compounds were characterized at different spectroscopic techniques like UV, FTIR, HPLC and AAS (atomic absorption spectroscopy). Biological screening of novel compounds was accomplished against diverse group of pathogens. Some of our novel compounds showed high efficacy against the pathogens as compare to parent composites. We have introduced Novel method for ceftriaxone assays at HPLC using simple and safe mobile phase through metal complexation. Toxicity studies were carried out in vitro and with ADMET software. Novel complexes were found less toxic as compare to parent compounds.

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Alfredson DA, Korolik V. 2007. Antibiotic resistance and resistance mechanisms in Campylobacter jejuni and Campylobacter coli. FEMS Microbiol. Lett 277, 123-132.

Aly A, Osman A, El-Maali NA, Al-Hazmi G. 2004. Thermal and photochemical behaviour of Zn (II) complexes of some cephalosporins. J. Therm. Anal. Calorim 75, 159-168.

Anacona J, Bravo A, Lopez ME. 2013. Cefoperazone metal complexes: synthesis and characterization. Journal of the Chilean Chemical Society 58, 1520-1523.

Anacona JR, GC. 2006 Synthesis and antibacterial activity of cefixime metal complexes. Transition Met Chem 31, 227–231.

Auda S, Mrestani Y, Fetouh M, Neubert R. 2008. Characterization and activity of cephalosporin metal complexes. Die Pharmazie- An International Journal of Pharmaceutical Sciences 63, 555-561.

Auda SH, Mrestani Y, Nies DH, Groβe C, Neubert RH. 2009. Preparation, physicochemical characterization and biological evaluation of cefodizime metal ion complexes. Journal of Pharmacy and Pharmacology 61, 753-758.

Chitterjea MN, a RS. 1993. Text Book of Biochemistry 814-830.

Curran RJ. 2009. Silver (I) complexes as antimicrobial and anticancer drugs. National University of Ireland Maynooth.

Davidson R, Cavalcanti R, Brunton JL, Bast DJ, de Azavedo JC, Kibsey P, Fleming C, Low DE. 2002. Resistance to levofloxacin and failure of treatment of pneumococcal pneumonia. New Engl. J. Med 346, 747-750.

El-Said A, Aly A, El-Meligy M, Ibrahim M. 2009. Mixed ligand zinc (II) and cadmium (II) complexes containing ceftriaxone or cephradine antibiotics and different donors. J Argent Chem Soc 97, 149-165.

Jacoby GA. 2005. Mechanisms of resistance to quinolones. Clin. Infect. Dis 41, S120-S126.

Newman LM, Wang SA, Ohye RG, O’Connor N, Lee MV, Weinstock HS. 2004. The epidemiology of fluoroquinolone-resistant Neisseria gonorrhoeae in Hawaii 2001. Clin. Infect. Dis 38, 649-654.

Reiss A, Chifiriuc MC, Amzoiu E, Spînu CI. 2014. Transition metal (II) complexes with cefotaxime-derived Schiff base: Synthesis, characterization, and antimicrobial studies. Bioinorg. Chem. Appl 2014.

Wang H, Dzink-Fox JL, Chen M, Levy SB. 2001. Genetic characterization of highly fluoroquinolone-resistant clinical Escherichia coli strains from China: role ofacrR mutations. Antimicrob. Agents Chemother 45, 1515-1521.

Williams DR. 1971. The metals of life: the solution chemistry of metal ions in biological systems. Van Nostrand-Reinhold.