The anthelmintic effects of probiotics against Giardia intestinalis infection: A narrative review

Paper Details

Research Paper 05/05/2024
Views (124) Download (18)
current_issue_feature_image
publication_file

The anthelmintic effects of probiotics against Giardia intestinalis infection: A narrative review

Maria Isabel B. Pineda, Giselle A. Muñoz, Aiden B. Perfecto, Pauline Ann P. Rimbao, Samantha Kyle B. Rosas, Dave Ken G. Sallao, Laarni Hannah C. Lacorte
Int. J. Biosci.24( 5), 161-171, May 2024.
Certificate: IJB 2024 [Generate Certificate]

Abstract

Giardia intestinalis, also known as Giardia lamblia or Giardia duodenale, is a parasite causing giardiasis, a diarrheal disease, infecting over 1 million people annually. It spreads through contaminated water or food, primarily via fecal-oral transmission. Diagnosis relies on stool examination, and treatment involves antibiotics like Metronidazole or Nitazoxanide. However, these medications may induce dangerous side effects. Probiotics, beneficial microbes with health benefits, offer an alternative approach to treating giardiasis, showing promising results in recent studies. A narrative review was employed for the study. The PRISMA method was used as an assessment tool, whereas the PICO tool was used to answer questions for this review. Investigating probiotics’ potential to combat Giardia intestinalis infection reveals promising strategies for addressing parasitic diseases through symbiotic approaches. Understanding the mechanisms behind probiotics’ anthelmintic effects is crucial for establishing their protective role in the host. This involves colonization and recovery of damaged intestinal mucosa, exclusion of pathogens, bacteriocin production, and modification of enzymatic activities, which act synergistically to regulate the normal function of tissues. The exploration of probiotics as a potential strategy for combating Giardia intestinalis infection has revealed promising anthelmintic effects with significant implications for preventive and therapeutic approaches to managing this prevalent gastrointestinal parasite.

VIEWS 44

Abd AL-Khaliq IM. 2019. Effect of Bifidobacterium probiotic in the treatment of giardiasis infection in mice. Baghdad Science Journal 16(4). https://doi.org/10.21123/bsj.2019.16.4.0849

Allain T, Chaouch S, Thomas M, Vallée I, Buret AG, Langella P, Grellier P, Polack B, BermúdezHumarán LG, Florent I. 2018. Bile-Salt-Hydrolases from the Probiotic Strain Lactobacillus johnsonii La1 Mediate Anti-giardial Activity in Vitro and in Vivo. Frontiers in Microbiology, 8. https://doi.org/10.3389/fmicb.2017.02707

Allain T, Chaouch S, Thomas M, Travers M-A, Valle I, Langella P, Grellier P, Polack B, Florent I, Bermúdez-Humarán LG. 2018. Bile salt hydrolase activities: A novel target to screen Anti-Giardia Lactobacilli? Frontiers in Microbiology 9. https://doi.org/10.3389/fmicb.2018.00089

Al-Megrin W, Mohamed S, Saleh M, Yehia H. 2021. Preventive role of probiotic bacteria against gastrointestinal diseases in mice caused by Giardia lamblia. Bioscience Reports 41(2). https://doi.org/10.1042/BSR20204114

Amer EI, Mossallam SF, Mahrous H. 2014. Therapeutic enhancement of newly derived bacteriocins against Giardia lamblia. Experimental Parasitology 146, 52–63. https://doi.org/10.1016/j.exppara.2014.09.005

Anjana, & Tiwari, S. K. 2022. Bacteriocin-producing probiotic lactic acid bacteria in controlling dysbiosis of the gut microbiota. Frontiers in Cellular and Infection Microbiology 12. https://doi.org/10.3389/fcimb.2022.851140

Breedveld A, Van Egmond M. 2019. IgA and FcαRI: Pathological Roles and Therapeutic Opportunities. Frontiers in Immunology 10. https://doi.org/10.3389/fimmu.2019.00553

Darbandi A, Asadi A, Ari MM, Ohadi E, Talebi, M, Zadeh MH, Emamie AD, Ghanavati R, Kakanj M. 2021. Bacteriocins: Properties and potential use as antimicrobials. Journal of Clinical Laboratory Analysis 36. https://doi.org/10.1002/jcla.24093

De Boever P, Verstraete W. 1999. Bile Salt Deconjugation by Lactobacillus Plantarum 80 and Its Implication for Bacterial Toxicity. Journal of Applied Microbiology 87(3), 345–352. https://doi.org/10.1046/j.1365-2672.1999.00019.x

De Freitas Fonseca J, Alvim LB, Nunes ÁC, Oliveira FMS, Da Silva Amaral R, Caliari MV, Nicoli JR, Neumann E, Gomes MA. 2019. Probiotic effect of Bifidobacterium longum 5 1A and Weissella paramesenteroides WpK4 on gerbils infected with Giardia lamblia. Journal of Applied Microbiology 127(4), 1184–1191. https://doi.org/10.1111/jam.14338

Farthing MJG, Keusch GT, Mc C. 1985. Effects of bile and bile salts on growth and membrane lipid uptake by Giardia lamblia. Possible implications for pathogenesis of intestinal disease. Journal of Clinical Investigation 76(5), 1727–1732. https://doi.org/10.1172/jci112162

Giardia infection (giardiasis) – Diagnosis & treatment – Mayo Clinic. 2022. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/giardia-infection/diagnosis-treatment/drc-20372790

Goyal N, Rishi P, Shukla G. 2013. Lactobacillus rhamnosus GG antagonizes Giardia intestinalis induced oxidative stress and intestinal disaccharidases: an experimental study. World Journal of Microbiology and Biotechnology 29(6), 1049–1057. https://doi.org/10.1007/s11274-013-1268-6

Hardy HN, Harris JR, Lyon E, Beal JD, Foey A. 2013. Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology. Nutrients 5(6), 1869–1912. https://doi.org/10.3390/nu5061869

Heilbronner S, Krismer B, BrötzOesterhelt H, Peschel A. 2021. The microbiome-shaping roles of bacteriocins. Nature Reviews Microbiology 19(11), 726–739. https://doi.org/10.1038/s41579-021-00569-w

Humen, M. A., De Antoni, G. L., Benyacoub, J., Costas, M. E., Cardozo, M., Kozubsky, L. E., Saudan, K., Boenzli-Bruand, A., Blum, S., Schiffrin, E. J., & Pérez, P. 2005. Lactobacillus johnsonii La1 Antagonizes Giardia intestinalis In Vivo. Infection and Immunity 73(2), 1265–1269. https://doi.org/10.1128/iai.73.2.1265-1269.2005

Khanna R, Vinayak VK, Mehta SK, Kumkum, & Nain, C. K. 1988. Giardia lamblia infection in immunosuppressed animals causes severe alterations to brush border membrane enzymes. Digestive Diseases and Sciences 33(9), 1147–1152. https://doi.org/10.1007/bf01535792

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, Clarke M, Devereaux PJ, Kleijnen J, Moher D. 2009. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. Journal of Clinical Epidemiology 62(10). https://doi.org/10.1016/j.jclinepi.2009.06.006

PlazaDíaz J, RuizOjeda FJ, Gil-Campos M,  Gil Á. 2019. Mechanisms of action of probiotics. Advances in Nutrition 10, S49–S66. https://doi.org/10.1093/advances/nmy063

Food and Agriculture Organization. 2006. Probiotics in food: Health and Nutritional Properties and Guidelines for Evaluation.

Ribeiro, De Oliveira DM, Oliveira FMS, Caliari MV, Martins FS, Nicoli JR, Torres MF, De Andrade MCN, Cardoso VN, Gomes MA. 2018. Effect of probiotic Saccharomyces boulardii in experimental giardiasis. Beneficial Microbes 9(5), 789–797. https://doi.org/10.3920/bm2017.0155

Sanad M, El Maaty DAEKA, El-Aal NFA, Al-Ghandour A, Farag AI, Mohammed A, Ismail T. 2020. Therapeutic Efficacy of Probiotics against Experimental Giardiasis: Histopathological, Histochemical and Ultrastructural Changes. Journal of the Egyptian Society of Parasitology 50(1), 21–32. https://doi.org/10.21608/jesp.2020.88747

Saracino MP, Vila CC, Baldi PC, Maglio DHG. 2021. Searching for the one(s): Using Probiotics as Anthelmintic Treatments. Frontiers in Pharmacology 12. https://doi.org/10.3389/fphar.2021.714198

Shaaban Y, Hassan Z, Hussein RR, Hassan AY, Salama DEA. 2021. Evaluation of the role of combined prebiotic and probiotic supplements as prophylactic and therapeutic agents against experimental giardiasis. Parasitologists United Journal 14(2), 193–203. https://doi.org/10.21608/puj.2021.83828.1124

Shady OMA, Shalash I, Elshaghabee FMF, Negm M, Yousef GAB, Rizk E. 2023. Evaluating the Effect of Lactobacillus casei FEGY 9973 and Curcumin on Experimental Giardiasis. Acta Parasitologica. https://doi.org/10.1007/s11686-023-00744-4

Shen J, Lai D, Wilson RA, Chen Y, Lf W, Yu Z, Li M, He P, Hide G, Sun X, Yang T, Wu ZD, Ayala F, Zhao L. 2017. Nitric oxide blocks the development of the human parasite Schistosoma japonicum. Proceedings of the National Academy of Sciences of the United States of America 114(38), 10214–10219. https://doi.org/10.1073/pnas.1708578114

Shukla G, Kamboj S, Sharma B. 2019. Comparative Analysis of Antigiardial Potential of Heat Inactivated and Probiotic Protein of Probiotic Lactobacillus rhamnosus GG in Murine Giardiasis. Probiotics and Antimicrobial Proteins 12(1), 271–279. https://doi.org/10.1007/s12602-018-9506-8

Singh S, Shukla G, Verma A. 2013. Oral administration of the probiotic Lactobacillus casei ameliorates gut morphology and physiology in malnourished-Giardia intestinalis-infected BALB/c mice. ISRN Parasitology, 1–8. https://doi.org/10.5402/2013/762638

Southcott E, Tooley KL, Howarth GS, Davidson GP, Butler RN. 2008. Yoghurts containing probiotics reduce disruption of the small intestinal barrier in Methotrexate-Treated rats. Digestive Diseases and Sciences 53(7), 1837–1841. https://doi.org/10.1007/s10620-008-0275-1

Transmission, Giardia, Parasites, CDC. 2021. Centers for Disease Control and Prevention. https://www.cdc.gov/parasites/giardia/infection-sources.html

Yousef AM, El-Bahaie ES, Ibrahim SM. 2020. Effects of Alternative Natural and Nanotherapies Versus Metronidazole On Giardiasis Infected Hamster. Journal of the Egyptian Society of Parasitology 50, 622-632. https://doi.org/10.21608/jesp.2020.131095

Zeibig EA. 1997. Clinical Parasitology: A Practical Approach. Elsevier Inc.