The anthelmintic effects of probiotics against Giardia intestinalis infection: A narrative review

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Research Paper 05/05/2024
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The anthelmintic effects of probiotics against Giardia intestinalis infection: A narrative review

Maria Isabel B. Pineda, Giselle A. Muñoz, Aiden B. Perfecto, Pauline Ann P. Rimbao, Samantha Kyle B. Rosas, Dave Ken G. Sallao, Laarni Hannah C. Lacorte
Int. J. Biosci.24( 5), 161-171, May 2024.
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Abstract

Giardia intestinalis, also known as Giardia lamblia or Giardia duodenale, is a parasite causing giardiasis, a diarrheal disease, infecting over 1 million people annually. It spreads through contaminated water or food, primarily via fecal-oral transmission. Diagnosis relies on stool examination, and treatment involves antibiotics like Metronidazole or Nitazoxanide. However, these medications may induce dangerous side effects. Probiotics, beneficial microbes with health benefits, offer an alternative approach to treating giardiasis, showing promising results in recent studies. A narrative review was employed for the study. The PRISMA method was used as an assessment tool, whereas the PICO tool was used to answer questions for this review. Investigating probiotics’ potential to combat Giardia intestinalis infection reveals promising strategies for addressing parasitic diseases through symbiotic approaches. Understanding the mechanisms behind probiotics’ anthelmintic effects is crucial for establishing their protective role in the host. This involves colonization and recovery of damaged intestinal mucosa, exclusion of pathogens, bacteriocin production, and modification of enzymatic activities, which act synergistically to regulate the normal function of tissues. The exploration of probiotics as a potential strategy for combating Giardia intestinalis infection has revealed promising anthelmintic effects with significant implications for preventive and therapeutic approaches to managing this prevalent gastrointestinal parasite.

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