The antitoxic, anticancer and antioxidant activity of thymoquinone derived from Nigella sativa L.

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Review Paper 08/07/2024
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The antitoxic, anticancer and antioxidant activity of thymoquinone derived from Nigella sativa L.

Salem H. Albalawi, Haddad A. El Rabey
Int. J. Biosci.25( 1), 179-187, July 2024.
Certificate: IJB 2024 [Generate Certificate]

Abstract

Recent research aims to find out natural herbal remedies for treating various diseases resulted from oxidative stress, environmental toxins and pollutants, especially due to the insufficient number of anti-toxin drugs. The currently available antitoxins are multivitamins, glutathione, and N-acetyl cysteine. No known antitoxins for treating the advanced stages of endotoxemia, bacterial septicemia associated with septicemia, or septic shock. Recent studies focused on natural products as antioxidants that have strong anti-toxic effects by counteracting the effect of oxidants and show great potential in combating the effects of free radicals and cases of high oxidative stress. In this study, we review the role of thymoquinone-the main constituent of Nigella sativa- in the suppression of carcinogens and as an adjuvant in treating other diseases. The therapeutic importance of herbal remedies is due to higher constituents of phenolic and phenolic derivatives antioxidant that scavenge the free radicals and reduce the oxidative, which leads to protecting the body from diseases arising from this higher concentration of free radicals such as diabetes, cancer, obesity and cardiovascular diseases. The current study aims to review the antioxidant and protective value of thymoquinone against all diseases produced from the higher oxidative stress.

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