The excitotoxic effect of monosodium glutamate on Zebra Fish (Danio rerio)

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Research Paper 12/12/2023
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The excitotoxic effect of monosodium glutamate on Zebra Fish (Danio rerio)

N. Malathi, J. Jaya Supa Sooriya, Cicy Joseph
Int. J. Biomol. & Biomed.17( 3), 7-12, December 2023.
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The sodium salt of glutamic acid is monosodium glutamate (MSG), also referred to as sodium glutamate is one of the most frequently used food additives in processed foods.  In addition to its flavour-enhancing properties, MSG has been linked to several toxicities like Obesity, metabolic issues, Chinese Restaurant Syndrome, neurotoxicity and detrimental effects on the reproductive system. The current study is geared up to shed light on the effect of monosodium glutamate on Danio rerio, a fresh water fish. The objective is to study the lethal and sub-lethal concentration of MSG and its effects on morphology and biochemical parameters like total protein and carbohydrate in Zebra fish. The toxicity assay was conducted for 96hrs and the dose of 23.98 ppm was taken as LC50. The tissues were taken from exposed and control fish, they are used for estimation of total carbohydrate and protein. The organisms showed statistically significant difference between exposed and control group. In this present study MSG has affected fish morphologically by discoloration, protrusion of eyes and the levels of proteins and carbohydrates decrease with increasing concentration of MSG, therefore it has effects on metabolism of the organism.


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