Transfusion transmitted infections among blood donors at a tertiary care teaching Hospital in South India

Paper Details

Research Paper 01/07/2017
Views (237) Download (11)
current_issue_feature_image
publication_file

Transfusion transmitted infections among blood donors at a tertiary care teaching Hospital in South India

W Vishnu Vandana, K Leela Rani
Int. J. Micro. Myco.6( 1), 24-31, July 2017.
Certificate: IJMM 2017 [Generate Certificate]

Abstract

Blood transfusion is an important mode of transmission of infections to recipients. Evaluating trends in the prevalence of transfusion transmissible infections among blood donors is essential for monitoring blood supply safety and donor screening effectiveness. This study aimed to assess the seroprevalence of transfusion-transmissible infections among blood donors in the blood bank of a tertiary care teaching hospital in Bangalore, India. All consenting blood donors were consecutively included from Jan 2012 to Dec 2015 and were screened for seroprevalence of HIV, HBV, HCV and syphilis. A total of 4087 donors were tested, out of which 2681(65.6%) were replacement donors, 1406 (34.5%) were voluntary donors and 93% were males, 6.5% were females. The overall seropositivity rates of HIV, HBV, HCV & Syphilis were respectively 0.2%, 0.75%, 0.34% & 0.3% respectively. None of them were positive for malarial parasite. Seropositivity was more among males than in females and in replacement donors when compared to voluntary donors. Thus there is the need for non-remunerated voluntary donor services to be instituted. Also further prevalence rates of HCV and Syphilis to be studied in this region as there is greater fluctuation among them so that necessary steps are taken to provide safe blood to the recipients.

VIEWS 16

Arora D, Arora B, Khetarpal A. 2010. Seroprevalence of HIV, HBV, HCV and syphilis in blood donors in southern Haryana. Indian journal of Pathology and microbiology 53(2), 308-309. DOI:10.4103/0377-4929.64295. PMID:20551540

Arshad A,  Borhany M,  Anwar N,  Naseer I,  Ansari R,  Boota S et al. 2016. Prevalence of transfusion transmissible infections in blood donors of Pakistan. BMC Hematol 16, 27. DOI:10.1186/s12878-016-0068-2.PMCID:PMC5116208.

Bedoya JA, Cortés Márquez MM, Cardona Arias JA. 2012. Seroprevalence of markers of transfusion transmissible infections in blood bank in Colombia. Rev Saúde Pública 46(6), 950-959. DOI:10.1590/S0034.89102012000600004.D:23503536.

Chandra T, Kumar A, Gupta A. 2009. Prevalence of transfusion transmitted infections in blood donors an Indian experience. Trop Doct 39, 152-154. DOI: 10.1258/td.2008.080330. PMID:19535750.

Datta S. 2008. An overview of molecular epidemiology of hepatitis B virus (HBV) in India. Virol Journal 5, 156. DOI: 10.1186/1743-422X-5-156. PMID:19099581.

Das BK, Gayen BK, Aditya S, Chakrovorty SK, Datta PK, Joseph A. 2011. Seroprevalence of Hepatitis B, Hepatitis C, and human immunodeficiency virus among healthy voluntary first-time blood donors in Kolkata. Ann Trop Med Public Health 4, 86-90. www. atmph. org/ text.asp?2011/4/2/86/85758

Deepti Sachan, Joy Varghese, Jensingh Joseph, Vijaya Srinivasan, Venkataraman Jayanthi, Mohamed Rela. 2013. HBs Ag Positive Patient Characteristics in Hospital and Blood Donation Camps. ISRN Hematol 2013, Article ID 67519. DOI: 10.1155/2013/675191.PMCID: PMC3777120.

Fernandes H, D’souza PF, D’souza PM. 2010. Prevalence of Transfusion Transmitted Infections in Voluntary and Replacement Donors. Indian J Hematol Blood Transfusion 26(3), 89-91. DOI:10.1007/s12288-010-0044-0.MCID: PMC3002083

Fiebig EW, Busch MP. 2008. Infectious disease screening. In: Technical manual. (16th Edtn). American Association of Blood Banks 241-278. ISBN: 978-1-305-07591-7 Last Scanned: 2017-06-29 09:37:12

Gauravi A. Dhruva, Amit H. Agravat, JD, Dalsania, Ankita A. Katara. Transfusion Transmitted Diseases/Infections among Blood donors in a Tertiary Care Hospital at Rajkot, Gujrat, India. 2014. International Research Journal of Medical Sciences 2(4), 16-19. www.isca. in/MEDI_SCI/Archive/v2/i4/4. ISCA-IRJMedS-2014 -019.pdf

Huggi Vishwanath, Gadwalkar Srikant R. Seroprevalance of transfusion transmissible infections among healthy voluntary blood donors in and around bellary, karnataka state, india. 2014. International Journal of Basic and Applied Medical Science 4(1), 108-11. www.cibtech.org/J-MEDICAL-SCIENCES/ PUBLICATIONS/2014/Vol 4No 1/JMS-21-068-VENUGOPAL-SEROPREVALANCE-INDIA.pdf

Karmakar PR, Shrivastava P, Ray TG. 2014. Seroprevalence of Transfusion Transmissible Infections Among Blood Donors at the Blood Bank of a Medical College of Kolkata. Indian Journal of Public Health 58(1), 61-64. DOI:10.4103/0019-557X.128172.PMID:24748361.

Khamankar Shubhangi T, Hiwale Kishor M, Bhagat Vijay M, Bhake Arvind S. 2014. Seroprevalence of transfusion transmitted infection and utility of blood units in a tertiary care hospital in Central India. Indian Journal of Basic and Applied Medical Research 4(1), 7-13.  www.ijbamr. com/pdf/December%202014%207-13.pdf. pdf

Kulkarni N. 2012. Analysis of the seroprevalence of HIV, HBs Ag, HCV and Syphilitic infections detected in the pretranfusion blood. International Journal of Blood Transfusio and Immunohematology 2, 1-3. Article ID:100006IJBTINK2012. DOI: 10.5348/ijbti-2012-6-SR-1.

Murtuza Shaikh, Bhople KS. 2015. Seroprevalence of Transfusion Transmitted Infections in blood donors at a rural based tertiary care teaching hospital in India. IOSR Journal of Dental and Medical Sciences 14(10), 29-32. DOI: 10.9790/0853-141072932.

Narahari S, Juwle A, Basak S, Saranath D. 2009. Prevalence and geographic distribution of Hepatitis C Virus genotypes in Indian patient cohort. Infect Genet Evol 9, 643-5. DOI:10.1016/j.meegid.2009.04.001.ID:19460332

Purushottam A. Giri, Jayant Deshpande D, Deepak, Phalke B. 2012. Seroprevalence of Transfusion Transmissible Infections Among Voluntary Blood Donors at a Tertiary Care Teaching Hospital in Rural Area of India. J Family Med Prim Care 1(1), 48-51. DOI:10.4103/2249-4863.94452.PMCID: PMC3893947

Sharma DC, Rai S, Bharat S, Iyenger S, Gupta S, Jain B. 2014. A 10 Years Comparative Study to Assess Trends in Seroprevalence of Transfusion Transmitted Infections among Blood Donors at Gwalior, India. Open Journal of Blood Diseases 4, 24-32. DOI: 10.4236/ojbd.2014.42004

Shrestha A, Ghimire P, Tiwari B, Rajkarnikar M. 2009. Transfusion-transmissible infections among blood donors in Kathmandu, Nepal. The Journal of Infection in Developing Countries 3(10), 794-797. https://doi.org/10.3855/jidc.311

Stokx J, Gillet P, Weggheleire A D, Casas E C, Maendaenda R, Beulane AJ, et al. 2011. Seroprevalence of transfusion transmissible infections and evaluation of the pre-donation screening performance at the Provincial Hospital of Tete, Mozambique. BMC Infectious Diseases 11, 141-148. DOI:10.1186/1471-2334-11-141.PMID:21605363.

Yang S, Jiao D, Liu, Ming Lv et al C. 2016. Seroprevalence of Human Immunodeficiency Virus, Hepatitis B and C Viruses and Treponema Pallidum Infections Among Blood Donors at Shiyan, Central China. BMC Infect Dis 16(1), 531. DOI: 10.1186/ s12879-016-1845-z. PMID: 27716251

Yedlapati, Bhawani P, Raghava, Rao Sudhakar V. 2010. Seroprevalence of transfusion transmissible infections among blood donors in a tertiary care hospital of Andhra Pradesh. Biology and Medicine 2(4), 45-48. www. biolmedonline.com/Articles/Vol2_4_45-48.pdf