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Health aspects of bilberry: A review on its general benefits

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Review Paper 01/04/2021
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Health aspects of bilberry: A review on its general benefits

Nofa Amjad, Sadia Salman, Sidra Khalid, Wajeeha Arooj, Fozia Zulfiqar, Shaista Selsbeel, Bazla Fatima, Akeela Mushtaq, Bushra Khan, Zunaira Ramzan, Misbah Arshad
Int. J. Biosci.18( 4), 173-188, April 2021.
Certificate: IJB 2021 [Generate Certificate]
Key: AnthocyaninAnti-inflammatoryAnti-oxidantsBilberryOxidative stress

Abstract

Bilberry (Vaccinusm myrtillus L.) is one among the most extravagant characteristic wellsprings of anthocyanins. These polyphenolic components offer bilberry its blue/dark shading and high inhibitor content, and that they are accepted to be the key bioactives liable for a few announced wellbeing points of interest of bilberry. in spite of the fact that bilberry is advanced most normally for up vision, it’s been accounted for to bring down glucose, to possess restorative medication and lipid-bringing down impacts, and to advertise inhibitor protection and lower aerophilous pressure. Accordingly, bilberry is of potential worth inside the treatment or impedance of conditions identified with irritation, dyslipidemia, hyperglycemia or enlarged aerophilous pressure, disorder (CVD), malignancy, diabetes, and madness and distinctive age related sicknesses. There are reports that bilberry has contradicted microorganism action. Berries are an upscale supply of a vast sort of unhealthful, healthy, and fictive mixes like a pigments, resin, artificial addtives resin sap bitter, aromatic hydrocarbon, and phenolic substances further as nutritious compounds like sugars, basic grease, carotenes, nutrients, and mine. Bioactivity mixes with berries have intense inhibitor, anticancer, anticarcinogenic, antibiotices, therapeutic medication, and anti-neuroprogressive effects, each in test tube and in living body.

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Asada T, Tamura H. 2012. Isolation of bilberry anthocyanidin 3-glycosides bearing ortho-dihydroxyl groups on the b ring by forming an aluminum complex and their antioxidant activity. Journal of agricultural and food chemistry 60(42), 10634-10640. https://doi.org/10.1021/jf302476n

Asgary S, RafieianKopaei M, Sahebkar A, Shamsi F, Goli‐malekabadi N. 2016. Anti‐hyperglycemic and anti‐hyperlipidemic effects of Vaccinium myrtillus fruit in experimentally induced diabetes (antidiabetic effect of Vaccinium myrtillus fruit). Journal of the Science of Food and Agriculture 96(3), 764-768. https://doi.org/ 10.1002

Ashour OM, Elberry AA, Alahdal AM, Al Mohamadi AM, Nagy AA, Abdel-Naim AB, Abdel-Sattar EA, Mohamadin AM. 2011. Protective effect of bilberry (Vaccinium myrtillus) against doxorubicin-induced oxidative cardiotoxicity in rats. Medical science monitor: international medical journal of experimental and clinical research 17(4), BR110.

Bao L, Abe K, Tsang P, Xu JK, Yao XS, Liu HW, Kurihara H. 2010. Bilberry extract protect restraint stress-induced liver damage through attenuating mitochondrial dysfunction. Fitoterapia 81(8), 1094-1101. https://doi.org/10.1016/j.fitote.4.

Bardhan R, Grady NK, Cole JR, Joshi A, Halas NJ. 2009. Fluorescence enhancement by Au nanostructures: nanoshells and nanorods. ACS nano 3(3), 744-752. https://doi.org/10.1021 /nn900

Betz M, Kulozik U. 2011. Whey protein gels for the entrapment of bioactive anthocyanins from bilberry extract. International Dairy Journal 21(9), 703-710. https://doi.org/10.1016/j.idairyj.2011.04.003.

Betz M, Steiner B, Schantz M, Oidtmann J, Mäder K, Richling E, Kulozik U. 2012. Antioxidant capacity of bilberry extract microencapsulated in whey protein hydrogels. Food Research International 47(1), 51-57. https:// doi.org /10.1016 /j.foodres.2012.01.010.

Biedermann L, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, Vavricka SR, Fried M, Weber A, Humpf HU, Peschke S. 2013. Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis—An open pilot study. Journal of Crohn’s and Colitis 7(4), 271-279. https:// doi.org/10.1016/j.crohns.2012.07.010.

Bornsek SM, Ziberna L, Polak T, Vanzo A, Ulrih NP, Abram V, Tramer F, Passamonti S. 2012. Bilberry and blueberry anthocyanins act as powerful intracellular antioxidants in mammalian cells. Food chemistry 134(4), 1878-1884. https:// doi.org /10.1016/j.foodchem.2012.03.092.

Bujor OC, Tanase C, Popa ME. 2019. Phenolic Antioxidants in Aerial Parts of Wild Vaccinium Species: Towards Pharmaceutical and Biological Properties. Antioxidants 8(12), 649. https:// doi.org/ 10.3390 /antiox8120649.

Čanadanović-Brunet J, Tumbas Šaponjac V, Stajčić S, Ćetković G, Čanadanović V, Ćebović T, Vulić J. 2019. Polyphenolic composition, antiradical and hepatoprotective activities of bilberry and blackberry pomace extracts. Journal of Berry Research 9(2), 349-362.  DOI: 10.3233/JBR-180362.

Carmen Crespo M, Visioli F. 2017. A brief review of blue-and bilberries’ potential to curb cardio-metabolic perturbations: focus on diabetes. Current Pharmaceutical Design 23(7), 983-988.

Četojević-Simin DD, Velićanski AS, Cvetković DD, Markov SL, Ćetković GS, Šaponjac VT, Vulić JJ, Čanadanović-Brunet JM, Djilas SM. 2015. Bioactivity of Meeker and Willamette raspberry (Rubus idaeus L.) pomace extracts. Food Chemistry 166, 407-413. https:// doi.org/ 10.1016/ j.foodchem. 2014.06.063.

Chan SW, Tomlinson B. 2020. Effects of Bilberry Supplementation on Metabolic and Cardiovascular Disease Risk. Molecules 25(7), 1653. https://doi.org /10.3390 molecules25071653.

Chen TY, Kritchevsky J, Hargett K, Feller K, Klobusnik R, Song BJ, Cooper B, Jouni Z, Ferruzzimg, Janle EM. 2015. Plasma bioavailability and regional brain distribution of polyphenols from apple/grape seed and bilberry extracts in a young swine model. Molecular nutrition & food research 59(12), 2432-2447. https:// doi.org /10.1002/mnfr.201500224.

Choi EH, Han JY, Kang JH, Kim MK, Chun HS. 2015. Alleviation of Doxorubicin-Induced Cardiocytotoxicity by Anthocyanin-Rich Bilberry (Vaccinium myrtillus L.) in H9c2 Cells by Antioxidative Effects. J Pharm Chem Biol Sci 3, 247-261.

Chu WK, Cheung SC, Lau R. 2011. Bilberry (Vaccinium myrtillus L.). Herbal Medicine 20115386, 55-71.

Cisowska A, Wojnicz D, Hendrich AB. 2011. Anthocyanins as antimicrobial agents of natural plant origin. Natural product communications 6(1), 1934578X1100600136. https://doi.org /10.1177%2 F1 934 578X11 00600136.

de Mello VD, Lankinen MA, Lindström J, Puupponen‐Pimiä R, Laaksonen DE, Pihlajamäki J, Lehtonen M, Uusitupa M, Tuomilehto J, Kolehmainen M, Törrönen R. 2017. Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes. Molecular nutrition & food research 61(9), 1700019. https://doi.org /10.1002 /mnfr.201700019.

DeFuria J, Bennett G, Strissel KJ, Perfield JW, Milbury PE, Greenberg AS, Obin MS. 2009. Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelae. The Journal of nutrition 139(8), 1510-1516. https:// doi.org/ 10.3945/jn.109.105155.

Domitrović R, Jakovac H. 2011. Effects of standardized bilberry fruit extract (Mirtoselect®) on resolution of CCl4-induced liver fibrosis in mice. Food and chemical toxicology 49(4), 848-854. https:// doi.org/10.1016/j.fct.2010.12.006.

Dutta S, Sadhukhan P, Saha S, Sil PC. 2017. Regulation of oxidative stress by different naturally occurring polyphenolic compounds: an emerging anticancer therapeutic approach. React. Oxyg. Species 3, 81-95.

Eman Mohamed AL, Ali MA. 2014. Effects of bilberry on deoxyribonucleic acid damage and oxidant-antioxidant balance in the lens, induced by ultraviolet radiation. The Malaysian Journal of Medical Sciences: MJMS 21(1), 11.

Gustinelli G, Eliasson L, Svelander C, Alminger M, Ahrné L. 2018. Supercritical CO2 extraction of bilberry (Vaccinium myrtillus L.) seed oil: Fatty acid composition and antioxidant activity. The Journal of Supercritical Fluids 135, 91-97. https://doi.org/10.1016/j.supflu.2018.01.002.

Habanova M, Saraiva JA, Haban M, Schwarzova M, Chlebo P, Predna L, Gažo J, Wyka J. 2016. Intake of bilberries (Vaccinium myrtillus L.) reduced risk factors for cardiovascular disease by inducing favorable changes in lipoprotein profiles. Nutrition Research 36(12), 1415-1422. https://doi.org/10.1016/j.nutres.2016.11.010.

Haga S, YiMin, Yamaki H, Jin S, Sogon T, Morita N, Ozaki M. 2019. Extracts of bilberry (Vaccinium myrtillus L.) fruits improve liver steatosis and injury in mice by preventing lipid accumulation and cell death. Bioscience, biotechnology, and biochemistry 83(11), 2110-2120. https://doi.org/ 10.1080/ 09168451.2019.1634514.

Hoggard N, Cruickshank M, Moar KM, Bestwick C, Holst JJ, Russell W, Horgan G. 2013. A single supplement of a standardised bilberry (Vaccinium myrtillus L.) extract (36% wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes controlled by diet and lifestyle. Journal of nutritional science 2. https:// doi.org/ 10.1017/jns.2013.16.

Huang W, Yan Z, Li D, Ma Y, Zhou J, Sui Z. 2018. Antioxidant and anti-inflammatory effects of blueberry anthocyanins on high glucose-induced human retinal capillary endothelial cells. Oxidative medicine and cellular longevity. https: //doi.org /10.1155 /2018/1862462.

Jiang X, Li X, Zhu C, Sun J, Tian L, Chen W, Bai W. 2019. The target cells of anthocyanins in metabolic syndrome. Critical reviews in food science and nutrition 59(6), 921-946. https:// doi.org/ 10.1080 /10408398.2018.1491022.

Jones MR, Lingampally A, Wu J, Sedighi J, Ahmadvand N, Wilhelm J, Vazquez-Armendariz AI, Herold S, Chen C, Zhang JS, Bellusci S. 2020. Evidence for Overlapping and Distinct Biological Activities and Transcriptional Targets Triggered by Fibroblast Growth Factor Receptor 2b Signaling between Mid-and Early Pseudoglandular Stages of Mouse Lung Development. Cells 9(5), 1274. https://doi.org /10.3 390 /cells9051274.

Juadjur A, Mohn C, Schantz M, Baum M, Winterhalter P, Richling E. 2015. Fractionation of an anthocyanin-rich bilberry extract and in vitro antioxidative activity testing. Food chemistry 167, 418-424. https://doi.org/10.1016/j .foodchem.2 014.

Kamiya K, Kobashi H, Fujiwara K, Ando W, Shimizu K. 2013. Effect of fermented bilberry extracts on visual outcomes in eyes with myopia: a prospective, randomized, placebo-controlled study. Journal of ocular pharmacology and therapeutics 29(3), 356-359. https://doi.org /10.1 089 /jop.2012.0098.

Karcheva-Bahchevanska DP, Lukova PK, Nikolova MM, Mladenov RD, Iliev IN. 2017. Effect of extracts of bilberries (Vaccinium myrtillus L.) on amyloglucosidase and α-glucosidase activity. Folia Medica 59(2), 197-202.

Karlsen A, Paur I, Bøhn SK, Sakhi AK, Borge GI, Serafini M, Erlund I, Laake P, Tonstad S, Blomhoff R. 2010. Bilberry juice modulates plasma concentration of NF-κB related inflammatory markers in subjects at increased risk of CVD. European journal of nutrition 49(6), 345-355. DOI: 10.1007/s00394-010-0092-0.

Karppinen K, Zoratti L, Sarala M, Carvalho E, Hirsimäki J, Mentula H, Martens S, Häggman H, Jaakola L. 2016. Carotenoid metabolism during bilberry (Vaccinium myrtillus L.) fruit development under different light conditions is regulated by biosynthesis and degradation. BMC plant biology 16(1), 1-16. DOI: 10.1186/s12870-016-0785-5.

Kohno T, Ichikawa H, Totoki Y, Yasuda K, Hiramoto M, Nammo T, Sakamoto H, Tsuta K, Furuta K, Shimada Y, Iwakawa R. 2012. KIF5B-RET fusions in lung adenocarcinoma. Nature medicine 18(3), 375-377. DOI:10.1038/nm.2644.

Korus A, Jaworska G, Bernaś E, Juszczak L. 2015. Characteristics of physico-chemical properties of bilberry (Vaccinium myrtillus L.) jams with added herbs. Journal of food science and technology 52(5), 2815-2823. DOI: 10.1007/s13197-014-1315-9.

Kosehira M, Machida N, Kitaichi N. 2020. A 12-Week-Long Intake of Bilberry Extract (Vaccinium myrtillus L.) Improved Objective Findings of Ciliary Muscle Contraction of the Eye: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Trial. Nutrients 12(3), 600. https:// doi.org / 10.3390/nu12030600.

Kowalska K, Olejnik A, Szwajgier D, Olkowicz M. 2017. Inhibitory activity of chokeberry, bilberry, raspberry and cranberry polyphenol-rich extract towards adipogenesis and oxidative stress in differentiated 3T3-L1 adipose cells. PLoS One 12(11), e0188583. https://doi.org/10.1371 /journal. pone..

Kowalska K, Olejnik A. 2016. Current evidence on the health-beneficial effects of berry fruits in the prevention and treatment of metabolic syndrome. Current opinion in clinical nutrition and metabolic care 19(6), 446-452. https://doi.org/ 10.1097/MCO. 0000000000000322.

Li J, Wu T, Li N, Wang X, Chen G, Lyu X. 2019. Bilberry anthocyanin extract promotes intestinal barrier function and inhibits digestive enzyme activity by regulating the gut microbiota in aging rats. Food & function 10(1), 333-343. https://doi.org/10.1039 .

Li J, Zhao R, Zhao H, Chen G, Jiang Y, Lyu X, Wu T. 2019. Reduction of Aging-Induced Oxidative Stress and Activation of Autophagy by Bilberry Anthocyanin Supplementation via the AMPK–mTOR Signaling Pathway in Aged Female Rats. Journal of agricultural and food chemistry 67(28), 7832-7843. https://doi.org/10.1021/acs.jafc.9b02567.

Li N, Li J, Hao J, Zhang M, Yin J, Geng J, Wu T, Lyv X. 2019. Bilberry anthocyanin improves the serum cholesterol in aging perimenopausal rats via the estrogen receptor signaling pathway. Food & function 10(6), 3430-3438. https://doi.org/10.1039.

Li SW. 2010. Effect of bilberry ingestion on biomarkers of health and antioxidant content: a study of antioxidant bioavailability and acute post-ingestion effects in a controlled human intervention trial.

Liobikas J, Skemiene K, Trumbeckaite S, Borutaite V. 2016. Anthocyanins in cardioprotection: a path through mitochondria. Pharmacological Research 113, 808-815. https:// doi.org /10.1016/ j. phrs. 2016.03.036.

Liu HY, Walden TB, Cai D, Ahl D, Bertilsson S, Phillipson M, Nyman M, Holm L. 2019. Dietary fiber in Bilberry Ameliorates pre-obesity events in rats by regulating lipid depot, cecal short-chain fatty acid formation and microbiota composition. Nutrients 11(6), 1350. https://doi.org/10.3390/ nu11

Luo H, Lv XD, Wang GE, Li YF, Kurihara H, He RR. 2014. Anti-inflammatory effects of anthocyanins-rich extract from bilberry (Vaccinium myrtillus L.) on croton oil-induced ear edema and Propionibacterium acnes plus LPS-induced liver damage in mice. International journal of food sciences and nutrition 65(5), 594-601. https:// doi.org/10.3109/09637486.2014.886184.

Matsunaga N, Imai S, Inokuchi Y, Shimazawa M, Yokota S, Araki Y, Hara H. 2009. Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo. Molecular nutrition & food research 53(7), 869-877. https://doi.org/10.1002/mnfr.200800394.

Matysek M, Mozel S, Szalak R, Zacharko-Siembida A, Obszanska K, Arciszewski MB. 2017. Effect of feeding with bilberry fruit on the expression pattern of alphaCaMKII in hippocampal neurons in normal and diabetic rats. Polish journal of veterinary sciences, 20(2).

Miyake S, Takahashi N, Sasaki M, Kobayashi S, Tsubota K, Ozawa Y. 2012. Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract: cellular and molecular mechanism. Laboratory investigation 92(1), 102-109. Doi:10.1038/labinvest.2011.132.

Mizuguchi Y, Tomioka F, Tsuda S, Yamaguchi T, Takano Y. 2008. Superconductivity at 27 K in tetragonal FeSe under high pressure. Applied Physics Letters 93(15), 152505.

Morrison MC, Liang W, Mulder P, Verschuren L, Pieterman E, Toet K, Heeringa P, Wielinga PY, Kooistra T, Kleemann R. 2015. Mirtoselect, an anthocyanin-rich bilberry extract, attenuates non-alcoholic steatohepatitis and associated fibrosis in ApoE∗ 3Leiden mice. Journal of hepatology 62(5), 1180-1186. https://doi.org/10.1016/j.jhep. 2014. 12.

Muqbil I, Banu N. 2006. Enhancement of pro-oxidant effect of 7, 12-dimethylbenz (a) anthracene (DMBA) in rats by pre-exposure to restraint stress. Cancer letters 240(2), 213-220. https:// doi.org/ 10.1016/j.canlet.2005.09.008.

Nguyen V, Tang J, Oroudjev E, Lee CJ, Marasigan C, Wilson L, Ayoub G. 2010. Cytotoxic effects of bilberry extract on MCF7-GFP-tubulin breast cancer cells. Journal of medicinal food 13(2), 278-285. https://doi.org /10.1089/jmf. 2009. 0053.

Nile SH, Park SW. 2014. Edible berries: Bioactive components and their effect on human health. Nutrition 30(2), 134-144. https://doi.org/ 10.1016/ j.nut.2013.04.007.

Ogawa K, Tsuruma K, Tanaka J, Kakino M, Kobayashi S, Shimazawa M, Hara H. 2013. The protective effects of bilberry and lingonberry extracts against UV light-induced retinal photoreceptor cell damage in vitro. Journal of agricultural and food chemistry 61(43), 10345-10353. https://doi.org/ 10.1021 /jf402772h.

Omar IAN. 2018. Effect of bilberry extract on slowing high-myopia progression in children: 2-year follow-up study. Clinical Ophthalmology (Auckland, NZ) 12, 2575. https://dx.doi.org/10.2147%2 FOPTH. S187949.

Ooe E, Kuse Y, Yako T, Sogon T, Nakamura S, Hara H, Shimazawa M. 2018. Bilberry extract and anthocyanins suppress unfolded protein response induced by exposure to blue LED light of cells in photoreceptor cell line. Molecular vision 24, 621.

Osada H, Okamoto T, Kawashima H, Toda E, Miyake S, Nagai N, Kobayashi S, Tsubota K, Ozawa Y. 2017. Neuroprotective effect of bilberry extract in a murine model of photo-stressed retina. PLoS One 12(6), e0178627. https://doi.org/ 10.1371/journal.pone.0178627.

Pires TC, Caleja C, Santos-Buelga C, Barros L, Ferreira IC. 2020. Vaccinium myrtillus L. fruits as a novel source of phenolic compounds with health benefits and industrial applications-a review. Current Pharmaceutical Design 26(16), 1917-1928. https:// doi.org/ 10.2174/1381612826666200317132507.

Popović D, Kocić G, Katić V, Jović Z, Zarubica A, Veličković LJ, Nikolić V, Jović A, Kundalić B, Rakić V, Ulrih NP. 2019. Protective effects of anthocyanins from bilberry extract in rats exposed to nephrotoxic effects of carbon tetrachloride. Chemico-biological interactions 304, 61-72. https://doi.org /10.1016 /j.cbi.2019.02.022.

Raudsepp P, Anton D, Roasto M, Meremäe K, Pedastsaar P, Mäesaar M, Raal A, Laikoja K, Püssa T. 2013. The antioxidative and antimicrobial properties of the blue honeysuckle (Lonicera caerulea L.), Siberian rhubarb (Rheum rhaponticum L.) and some other plants, compared to ascorbic acid and sodium nitrite. Food Control 31(1), 129-135. https://doi.org/10.1016/j.foodcont.2012.10.007.

Roth S, Spalinger MR, Gottier C, Biedermann L, Zeitz J, Lang S, Weber A, Rogler G, Scharl M. 2016. Bilberry-derived anthocyanins modulate cytokine expression in the intestine of patients with ulcerative colitis. PLoS One 11(5), e0154817. https://doi.org/10.1371/journal.pone.0154817.

Šaponjac VT, Čanadanović-Brunet J, Ćetković G, Djilas S, Četojević-Simin D. 2015. Dried bilberry (Vaccinium myrtillus L.) extract fractions as antioxidants and cancer cell growth inhibitors. LWT-Food Science and Technology 61(2), 615-621. https://doi.org/10.1016/j.lwt.2014.04.021.

Schantz M, Mohn C, Baum M, Richling E. 2010. Antioxidative efficiency of an anthocyanin rich bilberry extract in the human colon tumor cell lines Caco-2 and HT-29. Journal of berry research 1(1), 25-33. DOI:10.3233/BR-2010-003.

Shim SH, Kim JM, Choi CY, Kim CY, Park KH. 2012. Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma. Journal of medicinal food 15(9), 818-823. https://doi.org/10.1089/jmf.

Sidorova YS, Shipelin VA, Mazo VK, Zorin SN, Petrov NA, Kochetkova AA. 2018. Comparative studies of antidiabetic activity of bilberry leaf extract in Wistar rats with STZ-induced diabetes and Zucker diabetic fatty rats. International Food Research Journal 25(3).

Singh M, Nam DT, Arseneault M, Ramassamy C. 2010. Role of by-products of lipid oxidation in Alzheimer’s disease brain: a focus on acrolein. Journal of Alzheimer’s disease 21(3), 741-756. DOI: 10.3233/JAD-2010-100405.

Song J, Li Y, Ge J, Duan Y, Sze SC, Tong Y, Shaw PC, Ng TB, Tsui KC, Zhuo Y, Zhang KY. 2010. Protective effect of bilberry (Vaccinium myrtillus L.) extracts on cultured human corneal limbal epithelial cells (HCLEC). Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives 24(4), 520-524. https://doi.org/10.1002/ptr.2974.

Suzuki R, Tanaka M, Takanashi M, Hussain A, Yuan B, Toyoda H, Kuroda M. 2011. Anthocyanidins-enriched bilberry extracts inhibit 3T3-L1 adipocyte differentiation via the insulin pathway. Nutrition & Metabolism 8(1), 1-9. DOI: 10.1186/1743-7075-8-14.

Takikawa M, Inoue S, Horio F, Tsuda T. 2010. Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice. The Journal of nutrition 140(3), 527-533.

Tang X, Shen T, Jiang X, Xia M, Sun X, Guo H, Ling W. 2015. Purified anthocyanins from bilberry and black currant attenuate hepatic mitochondrial dysfunction and steatohepatitis in mice with methionine and choline deficiency. Journal of agricultural and food chemistry 63(2), 552-561. https://doi.org/10.1021/jf504926n.

Thornthwaite JT, Thibado SP, Thornthwaite KA. 2020. Bilberry anthocyanins as agents to address oxidative stress. In Pathology (pp. 179-187). Academic Press. https://doi.org/10.1016/B978-0-12-815972-9.00017-2.

Uleberg E, Rohloff J, Jaakola L, Trôst K, Junttila O, Häggman H, Martinussen I. 2012. Effects of temperature and photoperiod on yield and chemical composition of northern and southern clones of bilberry (Vaccinium myrtillus L.). Journal of Agricultural and Food Chemistry 60(42), 10406-10414. https://doi.org/10.1021/jf302924m.

Veljković M, Pavlović DR, Stojiljković N, Ilić S, Jovanović I, Poklar Ulrih N, Rakić V, Veličković L, Sokolović D. 2017. Bilberry: Chemical profiling, in vitro and in vivo antioxidant activity and nephroprotective effect against gentamicin toxicity in rats. Phytotherapy Research 31(1), 115-123. https://doi.org/10.1002 /ptr. 5738.

Wachtel-Galor S, Yuen J, Buswell JA, Benzie IF. 2011. Ganoderma lucidum (Lingzhi or Reishi). In Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. CRC Press/Taylor & Francis.

Walsh NP, Gleeson M, Pyne DB, Nieman DC, Dhabhar FS, Shephard RJ, Oliver SJ, Bermon S, Kajeniene A. 2011. Position statement part two: maintaining immune health. https://dspace.l boro. ac.uk /2134/10586.

Wang L, Jiang G, Jing N, Liu X, Li Q, Liang W, Liu Z. 2020. Bilberry anthocyanin extracts enhance anti-PD-L1 efficiency by modulating gut microbiota. Food & Function 11(4), 3180-3190. https:// doi.org/10.1039/D0FO00255K.

Xu YG, Zhang HH, Qiu HN, Ge WC, Wu FY. 2012. Oceanic crust components in continental basalts from Shuangliao, Northeast China: Derived from the mantle transition zone?. Chemical Geology 328, 168-184. https://doi.org/10.1016/ j.chem geo.2012.01.027.

Zoratti L, Klemettilä H, & Jaakola L. 2016. Bilberry (Vaccinium myrtillus L.) ecotypes. In Nutritional Composition of Fruit Cultivars (pp. 83-99). Academic Press. https://doi.org/10.1016/B978-0-12-408117-8.00004-0.

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