In vitro antioxidant and antiglycation studies on african mistletoe (T. bangwensis (Engler and K. Krause), Danser) and ring worm plant (S. alata (Linn.) Roxb) from Nigeria
Paper Details
In vitro antioxidant and antiglycation studies on african mistletoe (T. bangwensis (Engler and K. Krause), Danser) and ring worm plant (S. alata (Linn.) Roxb) from Nigeria
Abstract
The antioxidant activity of crude methanolic extracts and fractions of African mistletoe (Tapinanthus bangwensis) and Ring worm plant (Senna alata) leaves from Nigeria was investigated. In an in vitro free radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH), superoxide scavenging (SOS) activity and chelation of iron (II) ion [Fe2+] in the presence of ethylenediaminetetraacetic acid (EDTA), ethyl acetate (EtOAc) fractions of both plants showed antioxidant activity in DPPH (83.95±0.04 and 66.35±0.07%), SOS activity (86.10±0.03 and 83.14±0.07%) for T.bangwensis and S.alata respectively compared to control (n-propyl gallate) which showed 90.31±0.01% inhibition). Inhibition of Fe2+ chelation showed 84.29±0.06 and 81.59±0.04% for T.bangwensis and S.alata respectively when compared to control, EDTA (97.60±0.07%). Furthermore, in an advanced glycation end products (AGEs) study, the in vitro inhibition (≥50%) was highest in EtOAc fraction of S.alata (57.06±3.20 and 65.53±1.76%) at 0.25 and 0.5 mg/mL, respectively when compared to the control, rutin (86.00±1.50%). In conclusion, results of the study showed possible antioxidant as well as antiglycation potential of leaves of Tapinanthus bangwensis and Senna alata.
Ahmed N. 2005. Advanced glycation endproducts-role in pathology of diabetic complications. Diabetes Research and Clinical Practice 67, 3–21.
Al-Azzawie HF, Alhamdani MS. 2006. Hypoglycemic and antioxidant effect of oleuropein in alloxan-diabetic rabbits. Life Sciences 78, 1371-1377.
Ames BN, Gold LS, Willet WC. 1995. The causes and prevention of cancer. Proceedings of the National Academy of Sciences 92, 5258–5265
Ammara H, Salma R, Farah D, Shahid M. 2009. Antimicrobial activity of some plant extracts having hepatoprotective effects. Journal of Medicinal Plants Research 3, 020-023.
Apel K, Hirt H. 2004. Reactive oxygen species: metabolism, oxidative stress, and signal transduction. Annual Review of Plant Biology 55, 373-399.
Bassey P, Sowemimo A, Lasore O, Spies L, Venter M. 2012. Biological activities and nutritional value of Tapinanthus bangwensis leaves. African Journal of Biotechnology 11, 13821-13826.
Betteridge D J. 2000. What is oxidative stress. Metabolism 49, 3–8.
Blois MS. 1958. Antioxidant determination by the use of stable free radicals. Nature 26, 1199-1200.
Cerutti PA. 1994. Oxy-radicals and cancer. Lancet 344, 862–863.
Dimitrova AA, Atanasova MA, Georgieva MN, Russeva AL, Strashimirov DS, Baydanoff SI. 2010. Anti-age antibodies and markers of oxidative stress in spontaneously hypertensive rats at different ages. Journal of Biomedical and Clinical Research 3, 33-39.
Giugliano D, Ceriello A, Paolisso G. 1996. Oxidative stress and diabetic vascular complications. Diabetes Care 19, 257-267
Gutierrez RMP, Diaz1 SL, Reyes IC, Gonzalez AMN. 2010. Anti-glycation Effect of Spices and Chilies Uses in Traditional Mexican Cuisine. Journal of Natural Products 3, 95-102.
Halliwell B, Gutteridge JMC. 1995. The definition and measurement of antioxidants in biological systems. Free Radical Biology and Medicine 18, 125-126.
Halliwell B. 1996. Antioxidants in human health and disease. Annual Review of Nutrition 16, 33–50.
Halliwell B. 1997. Antioxidants and human diseases: a general introduction. Nutritional Reviews 55, 44–45.
Halliwell B. 1999. Antioxidant defence mechanisms: from the beginning to the end (of the beginning). Free Radical Research 31, 261–272.
Hamad I, Erol-Dayi O, Pekmez M, Onay-Ucar E, Arda N. 2010. Antioxidant and Cytotoxic Activities of Aphanes arvensis Extracts. Plant Foods for Human Nutrition 65, 44-49.
Hemmani T, Parihar MS. 1998. Reactive oxygen species and oxidative DNA damage, Indian Journal of Physiology and Pharmacology 42, 440-452.
Kanai S, Okano H. 1998. Mechanism of protective effects of sumac gall extract and gallic acid on progression of CC14-induced acute liver injury in rats. The American Journal of Chinese Medicine 26, 333-341
Krishna KL, Mruthunjaya K, Patel JA. 2010. Antioxidant and hepatoprotective potential of stem methanolic extract of Justicia gendarussa Burm. International Journal of Pharmacology 6, 78-80.
Lee SE, Hwang HJ, Ha JS, Jeong HS, Kim JH. 2003. Screening of medicinal plant extracts for antioxidant activity. Life Sciences 73, 167-179.
Lunceford N, Gugliucci A. 2005. Ilex paraguariensis extracts inhibit AGE formation more efficiently than green tea. Fitoterapia 76, 419-427.
Matersk M, Perucka I. 2005. Antioxidant activity of the main phenolic compounds isolated from hot pepper fruit (Capsicum annuum L.). Journal of Agriculture and Food Chemistry 53, 1750-1756.
Matsuda H, Wang T, Managi H, Yoshikawa M. 2003. Structural requirements of flavonoids for inhibition of protein glycation and radical scavenging activities. Bioorganic Medicinal Chemistry 11, 5317-5323.
Monnier VM. 2003. Intervention against the Maillard reaction in vivo. Archives of Biochemistry Biophysics 419, 1-15.
Naimiki M. 1990. Antioxidant/ antimutagens in foods. Critical Reviews in Food Science and Nutrition 29, 273-300.
Ozsoy N, Can A, Yanardag R, Akev N. 2008. Antioxidant activity of Smilax excelsa leaf extracts. Food Chemistry 110, 571-583.
Pietta PG. 2000. Flavonoids as antioxidants. Journal of Natural Products 63, 1035-1042.
Rahbar S, Figarola JL. 2003. Novel inhibitors of advanced glycation endproducts. Archives of Biochemistry and Biophysics 419, 63–79.
Sainami GS, Manika JS, Saimani RG. 1997. Oxidative stress: a key factor in pathogenesis of chronic diseases. Medical Update 1, 1-4.
Sanchez-Moreno C, Larrauri J, Saura-Calixto F. 1999. Free radical scavenging capacity of selected red and white wine. Journal of Science and Food Agriculture 791, 301.
Sanchez-Moreno C. 2002. Methods used to evaluate the free radical scavenging activity in foods and biological systems. Food Science and Technology International 8, 121-137
Semba RD, Nicklett EJ, Ferrucci L. 2010. Does accumulation of advanced glycation end products contribute to the aging phenotype? The Journal of Gerontology 65A, 963–975
Shimada K, Fujikawa K, Yahara K, Nakamura T. 1992. Anti-oxidative properties of xanthan on the antioxidation of soybean oil in cyclodextrin emulsion. Journal of Agriculture Food Chemistry 40, 945–948.
United Kingdom Prospective Diabetes Study. 1998. Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type-2 diabetes. Lancet 352, 837–851.
Yakubu MT, Musa IF. 2012. Effects of post-coital administration of alkaloids from Senna alata (Linn. Roxb) leaves on some fetal and maternal Outcomes of pregnant rats. Journal of Reproduction and Infertility 13, 211–217.
Yokozawa T, Nakagawa T. 2004. Inhibitory effects of Luobuma tea and its components against glucose-mediated protein damage. Food Chemistry Toxicology 42, 975-981.
Kingsley C.Patrick-Iwuanyanwu, Sajjad Ali, Muhammad Iqbal Choudhary, Muhammad Ismail, Saima Rasheed (2015), In vitro antioxidant and antiglycation studies on african mistletoe (T. bangwensis (Engler and K. Krause), Danser) and ring worm plant (S. alata (Linn.) Roxb) from Nigeria; JBES, V6, N1, January, P378-386
https://innspub.net/in-vitro-antioxidant-and-antiglycation-studies-on-african-mistletoe-t-bangwensis-engler-and-k-krause-danser-and-ring-worm-plant-s-alata-linn-roxb-from-nigeria/
Copyright © 2015
By Authors and International
Network for Natural Sciences
(INNSPUB) https://innspub.net
This article is published under the terms of the
Creative Commons Attribution License 4.0