home icon user icon
Welcome to International Network for Natural Sciences | INNS Pub.
Home My Account
Submit Manuscript
double_slash
breadcumb_bg

Anti-rubella antibodies seroprevalence among pregnant women, attending antenatal care at the Sino-Gabonese friendship hospital in Franceville

Paper Details

Research Paper 09/08/2024
Views (57) Download (11)
current_issue_feature_image
publication_file

Anti-rubella antibodies seroprevalence among pregnant women, attending antenatal care at the Sino-Gabonese friendship hospital in Franceville

Thiéry Ndong Mba, Hilaire Moundounga Kenguele, Cédric Sima Obiang, Kervaly Pierre Bithegue Mba, Ulrick Nzamba, Jean Bruno Mamboundou, Clay Archange Boupoya, Louis Clément Obame Engonga, Patrick Mickala
Int. J. Biosci.25( 2), 273-282, August 2024.
Certificate: IJB 2024 [Generate Certificate]
Key: Anti-rubella antibodiesFrancevilleFriendship Sino-Gabonese hospitalGabonPregnant womenSeroprevalence

Abstract

Pregnant women represent a population category at high risk of severe rubella infection, capable of adversely affecting their fetus. This study was conducted to determine the anti-rubella antibodies seroprevalence, among pregnant women attending antenatal care at the Sino-Gabonese Friendship Hospital in Franceville. A prospective, cross-sectional study was conducted at the Sino-Gabonese Friendship Hospital in Franceville, from April to June 2023. Using a structured, pre-established and pre-tested questionnaire, sociodemographic, and obstetrical characteristics, were obtained. Three milliliters of serum obtained after centrifugation of the 10 ml of blood sample collected from the participants, were used to measure rubella-specific IgG antibody levels using the OnSite Rapid Test Rubella IgG/IgM COMBO lateral flow immunochromatographic test. Results were considered significant at p≤0.05. The study included 107 pregnant women attending antenatal care. With a mean age of 27.9±7.1 years, anti-Rubella IgG antibodies were found in 87 pregnant women, indicating an overall seroprevalence of 81.30% (95% CI: [0.72 – 0.87). Of these, 6.9% (n = 6) of the women were serum anti-Rubivirus IgM carriers. In univariate analysis, it was indicated that pregnant women in the study aged between 21-30 years (OR =0.33; 95% CI: [0.12-0.9] p=0.0027), student (OR =6.35; 95% CI: [1.39-29.09] p=0.001), or without professional status (OR =0.05; 95% CI: [0.01- 0.27] p<0.001), high school education (OR =8.24; 95% CI: [2.83-23.96] p<0.001), single (OR =0.3; 95% CI: [0.11-0.85] p=0.0021) or cohabiting OR =3.91; 95% CI: [1.21-12.64] p=0.0017) Residing in an urban area (OR =49; 95% CI: [1.43-16.75] p=0.006), in the first trimester of their pregnancy (OR = 0.29; 95% CI: [0.09-0.94] p= 0.033), with a history of spontaneous abortion (OR = 0.09; 95% CI: [1.04; 11.30] p= 0. 037), and unvaccinated (OR = 0.13; 95% CI: [0.05; 0.13] p<0.000), had an elevated risk of Rubella, After adjusting of risk factors by logistic regression, residence in a rural area (aOR = 139.87 95% CI : [1.74 -11236.216] p=0.027), and no vaccination (aOR = 43.3 95% CI: [1.13 -1662.7] p= 0.043), were identified as the only significant risk factors for Rubella infection in the present study. The high rate of anti-rubella antibodies seroprevalence among pregnant women in the present study indicates that any short-term vaccination strategy aimed at reducing the number of susceptible women of childbearing age is imperative.

VIEWS 24
Cover PDF

And LW, Gao Q, Cui L. 2022. Prevalence of measles antibodies among migrant workers in Singapore: a serological study to identify susceptible population subgroups. BMC Infect Dis 22, 88. DOI: 10.1186/s12879-022-07066-2

Ategbo S, Ngoungou EB, Koko J, Vierin Y, Zang Ndong CE, Moussavou Mouyama A. 2010. Immunization coverage of children aged 0 to 5 years in Libreville (Gabon). Sante 20, 215-9.

Baker RE, Mahmud AS, Miller IF, Rajeev M, Rasambainarivo F, Rice BL, Takahashi S, Tatem AJ, Wagner CE, Wang LF, Wesolowski A, Metcalf CJE. 2022. Infectious disease in an era of global change. Nat Rev Microbiol 20(4), 193-205. DOI: 10.1038/s41579-021-00639-z.

Berg AH. 2022. Fighting rubella without vaccines: the Danish exception, 1941-1987. Social history of medicine 35(3), 888-909.

Camejo Leonor M, Méndez MD. 2023. Rubella. In StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; Jan-. PMID: 32644466

Dixon MG, Reef SE, Zimmerman LA, Grant GB. 2022. Past as prologue – Using lessons from the rubella vaccination program to inform COVID-19 vaccination. Emerg Infect Dis 28(13), S225-S231. DOI: 10.3201/eid2813.220604.

Ekuma UO, Ogbu O, Oli AN, Okolo MO, Edeh PA, Al-Dahmoshi HOM. 2022. The burden of probable rubella infection among healthy pregnant women in Abakaliki, Ebonyi State, Nigeria. Interdiscip Perspect Infect Dis 2022, 5743106. DOI: 10.1155/2022/5743106.

Fokunang CN, Chia J, Ndumbe P. 2010. Clinical studies on rubella virus seroprevalence in pregnant women in the regions of Cameroon. African Journal of Clinical and Experimental Microbiology 11 (2), 79-92. DOI:  10.4314/ajcem.v11i2.53913

Haabouni F, Messadi L, Fki Zribi M, Hammami A, Karray H. 2012. Seroprevalence of rubella in women of reproductive age two years after the introduction of vaccination in Tunisia. Pathology Biology 60(3), 170-173. DOI: 10.1016/j.patbio.2011.10.004.

Hamdan HZ, Abdelbagi IE, Nasser NM. 2011. Seroprevalence of cytomegalovirus and rubella in pregnant women in western Sudan. Virol J 8, 217. DOI: 10.1186/1743-422X-8-217

Jahromi AS, Kazemi A, Manshoori G, Madani A, Moosavy SH, Seddigh B. 2011. Rubella virus seroprevalence in women with spontaneous abortion. American J Infect Dis 7(1), 16.

Kolawole OM, Anjorin EO, Adekanle DA, Kolawole CF, Durowade KA. 2014. Seroprevalence of rubella IgG antibody in pregnant women in Oshogbo, Nigeria. Int J Prev Med 5(3), 287-92.

Lambert N, Strebel P, Orenstein W, Icenogle J, Poland GA. 2015. Rubella. Lancet 385(9984), 2297-307. DOI: 10.1016/S0140-6736(14)60539-0.

Lulandala L, Mirambo MM, Matovelo D, Gumodoka B, Mshana SE. 2017. Acute rubella virus infection in spontaneously aborted women in Mwanza City, Tanzania. J Clin Diagn Res 11(3), QC25-QC27. DOI: 10.7860/JCDR/2017/22634.9544.

Masresha B, Shibeshi M, Kaiser R, Luce R, Katsande R, Mihigo R. 2018. Congenital rubella syndrome in the African region – Sentinel surveillance data. J Immunol Sci Suppl, 146-150.

Mawson AR, Croft AM. 2019. Rubella virus infection, the congenital rubella syndrome, and the link to autism. Int J Environ Res Public Health 16(19), 3543. DOI: 10.3390/ijerph16193543.

Meng Q, Luo J, Li L, Shi W, Yu J, Shen Y, Li L, Wang Y, Yao K. 2018. Rubella seroprevalence among pregnant women in Beijing, China. BMC Infect Dis. 18(1), 130. DOI: 10.1186/s12879-018-3032-x.

Noubom M, Kombou Tseyep DG, Sama LF, Wam EC, Sadjeu S. 2018. Seroprevalence of IgM and IgG antibodies to rubella and associated risk factors in pregnant women attending the antenatal clinic of Bafoussam regional hospital, western region of Cameroon. J Trop Dis.6, 279. DOI: 10.4172/2329-891X.1000279.

Mirambo MM, Majigo M, Aboud S, Groß U, Mshana SE. 2015. Serological culprits of rubella infection in Africa in the pre-vaccination era: a systematic review. BMC Resolution Notes 8(1), 716. DOI: 10.1186/s13104-015-1711-x.

Muliyil DE, Singh P, Jois SK, Otiv S, Suri V, Varma V, Abraham AM, Raut C, Gupta M, Singh MP, Viswanathan R, Naik S, Nag V, Benakappa A, Bavdekar A, Sapkal G, Singh K, Gupta N, Verma S, Santhanam S, Mishra S, Bhatnagar A, Prasad GRV, Kolekar J, Raj N, Sabarinathan R, Sachdeva RK, George S, Chaudhary S, Verghese VP, Jagtap V, Bharadwaj M, Murhekar M. 2018. Sero-prevalence of rubella among pregnant women in India, 2017. Vaccine 36(52), 7909-7912. DOI: 10.1016/j.vaccine.2018.11.013.

Ntoutoum L. 2019. Food hygiene: AGASA looks at “street food.”

Olajide OM, Aminu M, Randawa AJ, Adejo DS. 2015. Seroprevalence of rubella-specific IgM and IgG antibodies among pregnant women seen in a tertiary hospital in Nigeria. Int J Womens Health 7, 75-83. DOI: 10.2147/IJWH.S68667.

Oyinloye SO, Amama CA, Daniel R. 2014. Rubella antibody seroprevalence survey among pregnant women in Maiduguri, Borno State, Nigeria. African Journal of Clinical and Experimental Microbiology 15, 151-7.

Prevention of Congenital Rubella Syndrome. 1999. Paediatr Child Health 4(2), 158-60.

Ramos-Morcillo AJ, Moreno-Martínez FJ, Susarte AMH, Hueso-Montoro C, Ruzafa-Martínez M. 2019. Social determinants of children’s health, family and personal hygiene: a comparative study. Int J Environ Res Public Health 16(23), 4713. DOI: 10.3390/ijerph16234713.

Sampedro A, Rodríguez-Granger J, Gómez C, Lara A, Gutierrez J, Otero A. 2013. Comparative evaluation of a new chemiluminescent test and ELISA for the detection of measles IgM. Clinical laboratory analysis journal 27(6), 477-480.

Shanmugasundaram D, Awasthi S, Dwibedi B, Geetha S, Jain M, Malik S, Patel B, Singh H, Tripathi S, Viswanathan R, Agarwal A, Bonu R, Jain S, Jena SK, Priyasree J, Pushpalatha K, Ali S, Biswas D, Jain A, Narang R, Madhuri S, George S, Kaduskar O, Kiruthika G, Sabarinathan R, Sapakal G, Gupta N, Murhekar MV.  2021. Burden of congenital rubella syndrome (CRS) in India based on cross-sectional serological survey data, 2017 and 2019-2020. PLoS Negl Trop Dis 15(7), e0009608. DOI: 10.1371/journal.pntd.0009608

Su Q, Feng Z, Hao L, Ma C, Hagan JE, Grant GB. 2021. Assessment of the burden of congenital rubella syndrome in China and evaluation of mitigation strategies: a metapopulation modeling study. Lancet Infect Dis 21(7), 1004-1013. DOI: 10.1016/S1473-3099(20)30475-8.

Tamirat B, Hussen S, Shimelis T. 2017. Rubella virus infection and associated factors among pregnant women attending antenatal clinics at public hospitals in Hawassa city, southern Ethiopia: a cross-sectional study. BMJ Open 7, e016824. DOI: 10.1136/bmjopen-2017-016824

Tulu B, Mekonnen D, Amsalu E, Zenebe Y, Getahun M. 2018. Rubella virus seroprevalence and associated factors among unvaccinated pregnant women in northwestern Ethiopia. Ethiopia J Health Dev.

Vynnycky E, Adams EJ, Cutts FT, Reef SE, Navar AM, Simons E, Yoshida LM, Brown DW, Jackson C, Strebel PM, Dabbagh AJ. 2016. Using seroprevalence and immunisation coverage data to estimate the global burden of congenital rubella syndrome, 1996-2010: A systematic review. PLoS One 11(3), e0149160. DOI: 10.1371/journal.pone.0149160.

Wondimeneh Y. 2018. Rubella virus infections and immune status among pregnant women before rubella vaccine introduction in Amhara Regional State, Ethiopia. Int J Infect Dis 76, 14-22. DOI: 10.1016/j.ijid.2018.07.024.

World Health Organization. 2018. Congenital rubella syndrome: standards for vaccine-preventable disease surveillance. Accessed on 12 July 2023.

Submit Manuscript