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A review on Nutraceuticals as a Therapeutic Agents

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Review Paper 01/11/2019
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A review on Nutraceuticals as a Therapeutic Agents

U. Ghani, S.S.H. Bukhari, S. Ullah, H. Rafeeq, M.M. Saeed, A. Amjad, M. Hussain, A. Akmal, F.T. Zahra, F. Qasim, T. Taufiq, S.A. Chand
Int. J. Biosci.15( 5), 326-340, November 2019.
Certificate: IJB 2019 [Generate Certificate]
Key: antioxidantsCardiovascular diseasesFlavonoidsNutraceuticalsOxidative stress

Abstract

Nutraceuticals is a broad term derived from nutrition and pharmaceutical. Nutraceuticals are foods or part of foods that play a significant role in maintaining many physiological functions to maintain the human health and in preventing and treating many acute and chronic diseases.  Nutraceuticals are divided into three main categories including herbs, nutrients and dietary supplements. Several herbal products are produced from various herbs. Nutrients are substances with established nutritional values such as vitamins, minerals and amino acids which are essential for improving our health. The food products which are used as nutraceuticals are dietary fibers, prebiotics, probiotics, polyunsaturated fatty acids, antioxidants, spices and some other types of types of herbs and natural foods. Probiotics are ingested for their positive advantages in the digestive tract or systemic area like in the liver, brain, vagina or blood stream. Antioxidants are very essential in the treatment of almost all diseases because most chronic diseases occur due to oxidative stress which mostly occurs due to aging and lack of dietary antioxidants. Flavonoids and phytochemicals have antioxidant properties due to which it act as therapeutic agents for various diseases such as anti-cancerous. Omega-3 polyunsaturated fatty acids (PUFAs) are used for lowering the high levels of cholesterol in cardiovascular diseases and many inflammatory diseases. The main focus of this review is on role of nutraceuticals in metabolic pathways for the prevention of various diseases such as diabetes mellitus, cardiovascular diseases, obesity and cancer and osteoporosis.

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Ferrari CKB, Torres EAFDS. 2003. Biochemical pharmacology of functional foods and prevention of chronic diseases of aging. Biomedicine & Pharmacotherapy 57(5-6), 251-260.

Altmann SW, Davis HR, Zhu LJ, Yao X, Hoos LM, Tetzloff G, Wang L. 2004. Niemann-Pick C1 like 1 protein is critical for intestinal cholesterol absorption. Science 303(5661), 1201-1204.

Amariles P, González LI, Giraldo NA. 2006. Prevalence of self-treatment with complementary products and therapies for weight Loss: A randomized, cross-sectional study in overweight and obese patients in Colombia. Current therapeutic research 67(1), 66-78.

Arvanitoyannis IS, Van Houwelingen-Koukaliaroglou M. 2005. Functional foods: a survey of health claims, pros and cons, and current legislation. Critical reviews in food science and nutrition 45(5), 385-404.

Bar-Sela G, Epelbaum R, Schaffer M. 2010. Curcumin as an anti-cancer agent: review of the gap between basic and clinical applications. Current medicinal chemistry 17(3), 190-197.

Batra P, Sharma AK. 2013. Anti-cancer potential of flavonoids: recent trends and future perspectives. 3 Biotech 3(6), 439-459.

Baynes JW, Thorpe SR. 1999. Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes 48(1), 1-9.

Bell SJ, Goodrick GK. 2002. A functional food product for the management of weight. Critical reviews in food science and nutrition 42(2), 163-178.

Blankson H, Stakkestad JA, Fagertun H, Thom E, Wadstein J, Gudmundsen O. 2000. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. The Journal of nutrition 130(12), 2943-2948.

Borlinghaus J, Albrecht F, Gruhlk MC, Nwachukwu ID, Slusarenko AJ. 2014. Allicin: chemistry and biological properties. Molecules 19(8), 12591-12618.

Chan DC, Watt GF, Mori TA, Barrett PHR, Redgrave TG, Beilin LJ. 2003. Randomized controlled trial of the effect of n–3 fatty acid supplementation on the metabolism of apolipoprotein B-100 and chylomicron remnants in men with visceral obesity. The American journal of clinical nutrition 77(2), 300-307.

Chertow B. 2004. Advances in diabetes for the millennium: vitamins and oxidant stress in diabetes and its complications. Medscape general medicine 6(3).

Cicero AF, Colletti A, Bajraktari G, Descamps O, Djuric DM, Ezhov M, Panagiotakos DB. 2017. Lipid-lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel. Nutrition reviews 75(9), 731-767.

Cicero AF, Parini A, Rosticci M. 2015.Nutraceuticals and cholesterol-lowering action. International Journal of Cardiology Metabolic & Endocrine 6, 1-4.

Da Costa JP. 2017. A current look at nutraceuticals–key concepts and future prospects. Trends in Food Science & Technology 62, 68-78.

Danaei G, Ding EL, Mozaffarian D, Taylor B, Rehm J, Murray CJ, Ezzati M. 2009. The preventable causes of death in the United States: comparative risk assessment of dietary, lifestyle, and metabolic risk factors. PLoSmedicin 6(4), e1000058.

Dauchy RT, Blask DE, Sauer LA, Davidson LK, Krause JA, Smith LC, Dauchy EM. 2003. Physiologic melatonin concentration, omega-3 fatty acids, and conjugated linoleic acid inhibit fatty acid transport in rodent hind limb skeletal muscle in vivo. Comparative medicine 53(2), 186-190.

Dembinska-Kiec A, Mykkänen O, Kiec-Wilk B, Mykkänen H. 2008. Antioxidant phytochemicals against type 2 diabetes. British Journal of Nutrition 99(E-S1), ES109-ES117.

Devaraj S, Jialal I. 2006.The role of dietary supplementation with plant sterols and stanols in the prevention of cardiovascular disease. Nutrition reviews 64(7), 348-354.

Dubnov G, Brzezinski A, Berry EM. 2003. Weight control and the management of obesity after menopause: the role of physical activity. Maturitas 44(2), 89-101.

Evans JL, Goldfine ID. 2016. A new road for treating the vascular complications of diabetes: so let’s step on the gas. Diabetes 65(2), 346-348.

Ferguson JJ, Stojanovski E, MacDonald-Wicks L, Garg ML. 2016. Fat type in phytosterol products influence their cholesterol-lowering potential: a systematic review and meta-analysis of RCTs. Progress in lipid research 64, 16-29.

Francis G, Kerem Z, Makkar HP, Becker K. 2002. The biological action of saponins in animal systems: a review. British journal of Nutrition 88(6), 587-605.

Ghosh D, Choudhury ST, Ghosh S, Mandal AK, Sarkar S, Ghosh A, Das N. 2012. Nanocapsulated curcumin: oral chemopreventive formulation against diethylnitrosamine induced hepatocellular carcinoma in rat. Chemico-biological interactions 195(3), 206-214.

Graf GA, Li WP, Gerard RD, Gelissen I, White A, Cohen JC, Hobbs HH. 2002. Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface. The Journal of clinical investigation 110(5), 659-669.

Guazelli CF, Fattori V, Colombo BB, Georgetti SR, Vicentini FT, Casagrande R, VerriJr WA. 2013. Quercetin-loaded microcapsules ameliorate experimental colitis in mice by anti-inflammatory and antioxidant mechanisms. Journal of natural products 76(2), 200-208.

Gupta RC. 2016. Nutraceuticals: Efficacy, Safety and Toxicity London, U.K.: Academic 944 Press.

Harris WS, Bulchandani D. 2006. Why do omega-3 fatty acids lower serum triglycerides?. Current opinion in lipidology 17(4), 387-393.

Ingole SP, Kakde AU, Bonde PB. 2016. A Review on Statistics of Cancer in India. Journal. Environ. Science.Toxicol. Food Technol 10(7), 107-116.

Jayaprakasam B, Vareed SK, Olson LK, Nair MG. 2005. Insulin secretion by bioactive anthocyanins and anthocyanidins present in fruits. Journal of Agricultural and Food Chemistry 53(1), 28-31.

Kaiser Ν, Leibowitz G, Nesher R. 2003.Glucotoxicity and β-cell failure in type 2 diabetes mellitus. Journal of Pediatric Endocrinology and Metabolism 16(1), 5-22.

Kobayashi K, Saito Y, Nakazawa I, Yoshizaki F. 2000. Screening of crude drugs for influence on amylase activity and postprandial blood glucose in mouse plasma. Biological and Pharmaceutical Bulletin 23(10), 1250-1253.

Korotchkina LG, Sidhu S, Patel MS. 2004. R-lipoic acid inhibits mammalian pyruvate dehydrogenase kinase. Free radical research 38(10), 1083-1092.

Kotecha R, Takami A, Espinoza JL. 2016. Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence. Oncotarget 7(32), 52517.

Lavigne C, Tremblay F, Asselin G, Jacques H, Marette A. 2001. Prevention of skeletal muscle insulin resistance by dietary cod protein in high fat-fed rats. American Journal of Physiology-Endocrinology and Metabolism 281(1), E62-E71.

Martineau LC, Couture A, Spoor D, Benhaddou-Andaloussi A, Harris C, Meddah B, Prentki M. 2006. Anti-diabetic properties of the Canadian lowbush blueberry Vacciniumangustifolium Ait. Phytomedicine 13(9-10), 612-623.

McClements DJ. 2014. Nanoparticle-and microparticle-based delivery systems: Encapsulation, protection and release of active compounds. CRC Press.

McCue P, Kwon YI, Shetty K. 2005. Anti-diabetic and anti-hypertensive potential of sprouted and solid-state bioprocessed soybean. Asia pacific Journal of clinical nutrition 14(2), 145.

Mehta D. 2017. Integrative medicine and cardiovascular disorders. Primary Care: Clinics in Office Practice 44(2), 351-367.

Mermel VL. 2004. Old paths new directions: the use of functional foods in the treatment of obesity. Trends in food science & technology 15(11), 532-540.

Montonen J, Knekt P, Järvinen R, Reunanen A. 2004. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 27(2), 362-366.

Naeem M, Hayat M, Qamar SA, Mehmood T, Munir A, Ahmad G, Azmi UR, Faryad MA, Talib MZ, Irfan M, Hussain A, Hayder MA, Ghani U, Mehmood F. 2019.Risk factors, genetic mutations and prevention of breast cancer. Int. J. Biosci. 14(4), 492-496,

Perera PK, Li Y. 2012. Functional herbal food ingredients used in type 2 diabetes mellitus. Pharmacognosy reviews 6(11), 37.

Perrone D, Ardito F, Giannatempo G, Dioguardi M, Troiano G, Lo Russo L, Lo Muzio L. 2015. Biological and therapeutic activities, and anticancer properties of curcumin. Experimental and therapeutic medicine 10(5), 1615-1623.

Pietta PG. 2000. Flavonoids as antioxidants. Journal of natural products 63(7), 1035-1042.

Plat J, Mensink RP. 2005. Plant stanol and sterol esters in the control of blood cholesterol levels: mechanism and safety aspects. The American journal of cardiology 96(1), 15-22.

Ried K. 2016. Garlic Lowers Blood Pressure in Hypertensive Individuals, Regulates Serum Cholesterol, and Stimulates Immunity: An Updated Meta-analysis and Review, 2. The Journal of nutrition 146(2), 389S-396S.

Shishikura Y, Khokhar S, Murra BS. 2006. Effects of tea polyphenols on emulsification of olive oil in a small intestine model system. Journal of agricultural and food chemistry 54(5), 1906-1913.

Shukla Y, Singh R. 2011. Resveratrol and cellular mechanisms of cancer prevention. Annals of the New York Academy of Sciences 1215(1), 1-8.

Silverman MG, Ference BA, Im K, Wiviott SD, Giugliano RP, Grundy SM, Sabatine MS. 2016. Association between lowering LDL-C and cardiovascular risk reduction among different therapeutic interventions: a systematic review and meta-analysis. Jama 316(12), 1289-1297.

Spoorthi BC, Gautham SA, More SS, Maiti AK. 2018. Nutraceuticals: Potential therapeutic agents for the treatment and prevention of cardiovascular diseases. Journal of Pharmacy Research 12(2), 231.

Ting Y, Jiang Y, Ho CT, Huang Q. 2014. Common delivery systems for enhancing in vivo bioavailability and biological efficacy of nutraceuticals. Journal of Functional Foods 7, 112-128.

Watanabe J, Kawabata J, Kurihara H, Niki R. 1997. Isolation and identification of α-glucosidase inhibitors from tochu-cha (Eucommiaulmoides). Bioscience, biotechnology, and biochemistry 61(1), 177-178.

Way TD, Lin HY, Kuo DH, Tsai SJ, Shieh JC, Wu JC, Li JK. 2009. Pu-erh tea attenuates hyperlipogenesis and induces hepatoma cells growth arrest through activating AMP-activated protein kinase (AMPK) in human HepG2 cells. Journal of agricultural and food chemistry 57(12), 5257-5264.

Yang CS, Li G, Yang Z, Guan F, Chen A, Ju J. 2013. Cancer prevention by tocopherols and tea polyphenols. Cancer letters 334(1), 79-85.

Yang F, Song L, Wang H, Wang J, Xu Z, Xing N. 2015. Quercetin in prostate cancer: Chemotherapeutic and chemopreventive effects, mechanisms and clinical application potential. Oncology reports 33(6), 2659-2668.

Young JF, Dragsted LO, Haraldsdottir J, Daneshvar B, Kall MA, Loft S, Huynh-Ba T. 2002. Green tea extract only affects markers of oxidative status postprandially: lasting antioxidant effect of flavonoid-free diet. British Journal of Nutrition 87(4),

Zhu W, Qin W, Zhang K, Rottinghaus GE, Chen YC, Kliethermes B, Sauter ER. 2012. Trans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancer. Nutrition and cancer 64(3), 393-400.

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