Comparative study of biological characteristics between paediatric hepatocellular tumors and adult hepatocellular carcinoma
Paper Details
Comparative study of biological characteristics between paediatric hepatocellular tumors and adult hepatocellular carcinoma
Abstract
The biological differences between paediatric hepatocytic tumours (pHCT) and adult hepatocellular carcinoma (aHCC) remain unclear. This study aimed to compare the expression of hepatocyte-specific proteins, liver stem cell markers, and sinusoidal endothelial cell proteins in pHCTs and aHCCs using immunohistochemistry. A retrospective analysis identified 31 cases of pHCTs (24 hepatoblastomas and 7 paediatric hepatocellular carcinomas) treated at our hospital and other hospitals, where tumour biopsy or liver resection was performed. Pathological features were compared with 36 cases of aHCC. Tumour markers, including Hep Par-1, Arginase1, Glypican3 (GPC3), AFP, CD56, C-kit, and CD34, were examined. GPC3 was expressed in all pHCTs except for one hepatoblastoma case, while it was detected in only 18/36 aHCC cases, particularly those without chronic liver disease in adjacent tissue. HepPar-1 was expressed in all paediatric and adult tumours except for one pHCT case, and Arginase1 and AFP were universally expressed. CD56 and c-kit were not identified in any tumours, and CD4 expression was absent in sinusoidal microvascular endothelial cells, but CD34 was consistently expressed in all cases. These findings reveal significant biological differences between pHCC and aHCC, highlighting GPC3 as a potential characteristic marker of paediatric hepatocytic tumours.
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