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Detection of mycotoxins through nanobiosensors based on nanostructured materials: A review

Review Paper | May 1, 2019

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Nadezhda Sertova, Maya Ignatova

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Int. J. Biosci.14( 5), 106-115, May 2019

DOI: http://dx.doi.org/10.12692/ijb/14.5.106-115


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Mycotoxins are secondary metabolites produced by fungi which can affect a variety of feedstuffs.These compounds elicit toxicological effects which represent risk for both humans and animals. Several sensitive methods for detection of mycotoxins based on chromatographic or immunochemical techniques are currently commercially available. The toxicity of mycotoxins occurs at very low concentrations, consequently there is a need of sensitive and reliable methods for their detection.The emerging nanotechnology has opened novel opportunities to explore analytical applications of the fabricated nano-sized materials. With the advent of nanotechnology and its impact on developing ultrasensitive devices, mycotoxins analysis is benefiting also from the advances taking place in applying nanomaterials in sensors development. During the last years, the highlight was put on nanoscale materials included in biosensors, which were some of the smart devices used for biomolecular detection. The using of nanoscale materials for biosensing systems has seen explosive increase in the recent years. The nanostructures such as nanoparticles, nanowires and nanorods could be considered as promising materials for construction of biosensors, facilitating the great improvement of the selectivity and sensitivity of the current methods. Implementation of nanomaterials in the fabrication of nanobiosensors and their use for the detection of mycotoxins in food and feed is the centre focus of interest of the current research work of many scientists.


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Detection of mycotoxins through nanobiosensors based on nanostructured materials: A review

Ajayan PM, Zhou OZ. 2001. Applications of Carbon Nanotubes. In: Dresselhaus M.S., Dresselhaus G., Avouris P. (eds) Carbon Nanotubes. Topics in Applied Physics, 80. Springer, Berlin, Heidelberg, 391-425. https://doi.org/10.1007/3-540-39947-X_14

Bonel L, Vidal J, Duato P, Castillo J. 2010. Ochratoxin A nanostructured electrochemical immunosensors based on polyclonal antibodies and gold nanoparticles coupled to the antigen. Analytical Methods 2, 335- 341. http://dx.doi.org/10.1039/B9AY00297A

Bonnemann H, Richards R. 2001. Nanoscopic metal particles — synthetic methods and potential applications. European Journal of Inorganic Chemistry 10, 2455-2480.

Chen J, Li S, Yao D, Liu D.2009. Detection of sterigmatocystin based on the novel aflatoxin-oxidase/chitosan single-walled carbon nanotubes/poly-o-phenylenediamine modified electrode. Chinese Journal of Biotechnology 25, 2029–2035.

Cozzini P, Ingletto G, Singh R, Asta CD.2008. Mycotoxin Detection Plays “Cops and Robbers”: Cyclodextrin Chemosensors as Specialized Police? International Journal of Molecular Science 9, 2474-2494. http://dx.doi.org/10.3390/ijms912247

Diler E, Obst U, Schmitz K, Schwartz T. 2011. A lysozyme and magnetic bead based method of separating intact bacteria. Analytical and Bioanalytical Chemistry 401, 253–265. https://doi.org/10.1007/s00216-011-5065-5

Fernandez-Blado MA, Messina GA, Sanz MI, Raba J. 2009. Screen printed immunosensor modified with carbon nanotubes in a continuous- flow system for the Botritiscynerea  determination in apple tissues. Talanta 79, 681-686. https://doi.org/10.1016/j.talanta.2009.04.059

Gaag BVD, Spath S, Dietrich H, Stigter E, Boonzaaijer G, Osenbruggen TV, Koopal K.2003. Biosensors and multiple mycotoxins analysis. Food Control 14,251–254. https://doi.org/10.1016/S0956-7135(03)00008-2

Gan P, Ikeda K, Ireida H, Narusaka M, O’Connell RJ, Narusaka Y, Takano Y,Kubo Y, Shirasu K.2013. Comparative genomic and transcriptomic analyses reveal the hemibiotrophic stage shift of Colletotrichum fungi. New Phytologist 197,1236-1249. https://doi.org/10.1111/nph.12085

Holzinger M, Goff AL, Cosnier S. 2014. Nanomaterials for biosensing applications: a review. Frontiers in Chemistry 2, 63. https://doi.org/10.3389/fchem.2014.00063

Hu Y, Shen G, Zhu H, Jiang G. 2010. A class-specific enzyme-linked immunosorbent assay based on magnetic particles for multiresidue organophosphorus pesticides. Journal of Agricultural and Food Chemistry 58, 2801–2806. http://dx.doi.org/10.1021/jf903897k

Jogee PS, Ingle AP, Gupta IR, Bonde SR, Rai MK. 2012. Detection and management of mycotoxigenic fungi in nuts and dry fruits. ActaHort i963, 69–78. https://doi.org/10.17660/ActaHortic.2012.963.10

Köppen R, Koch M, Siegel D, Merkel S, Maul R, Nehls I. 2010. Determination of mycotoxins in foods: current state of analytical methods and limitations. Applied microbiology and biotechnology 86, 1595-1612. http://dx.doi.org/10.1007/s00253-010-2535-1

Kumar R, Somvir, Singh S, Kulwant. 2014. A Review on Application of Nanoscience for Biosensing. International Journal of Engineering Research 3, 279-285. http://dx.doi.org/10.1016/j.snb.2005.07.008

Kuo HT, Yeh JZ, Jiang CM, Wu MC. 2012. Magnetic particle-linked anti hCG β antibody for immunoassay of human chorionic gonadotropin (hCG), potentialapplication to early pregnancy diagnosis. J. Immunol. Methods 381, 32–40. http://dx.doi.org/10.1016/j.jim.2012.04.006

Ligler FS, Taitt CR, Shriver-Lake LC, Sapsford KE, Shubin Y, Golden JP. 2003. Array biosensor for detection of toxins. Analytical Bioanalytical Chemistry 377, 469–477. https://doi.org/10.1007/s00216-003-1992-0

Liu A. 2008. Towards development of chemosensors and biosensors withmetal-oxide based nanowires and nanotubes. Biosensors Bioelectronics 24, 167–177. https://doi.org/10.1016/j.bios.2008.04.014

Malhotra BD, Srivastava S, Augustine S. 2015. Biosensors for food toxin detection: carbon nanotubes and graphene. Materials Research Society Symposium Proceedings 1725. http://dx.doi.org/10.1557/opl.2015.165

Ohne K, Kani S, Ohashi M, Shinkai N, Inoue T, Wakimoto Y, Tanaka Y. 2013. Clinical evaluation of a newly developed high-sensitive detection of hepatitis B virus surface antigen by a semi-automated immune complex transfer chemiluminescent enzyme immunoassay. Rinsho Byori61, 787–794.

Pappert G, Rieger M, Niessner R, Seidel M. 2009. Immunomagnetic nanoparticle-based sandwich chemiluminescence-ELISA for the enrichment and quantification of E. coli. Microchimica Acta 168, 1–8. http://dx.doi.org/10.1007/s00604-009-0264-x

Radoi A, Targa M, Prieto-Simon B, Marty JL. 2008. Enzyme-linkedimmunosorbent assay (ELISA) based on superparamagnetic nanoparticles for aflatoxin M1 detection. Talanta 77, 138-143. http://dx.doi.org//10.1016/j.talanta.2008.05.048

Sapsford KE, Ngundi MM, Moore MH, Lassman ME, Shriver-Lake LC, Taitt CR, Ligler FS. 2006. Rapid Detection of Food Born Contaminants Using an Array Biosensor. Sensors and Actuators B Chemical 113, 599-607. https://doi.org/10.1016/j.snb.2005.07.008

Sertova NM. 2015. Application of nanotechnology for detection of mycotoxins and in agricultural sector. Journal of Central European Agriculture 16, 117–130. http://dx.doi.org/10.5513/JCEA01/16.2.1597

Shim WB, Kim KY, Chung DH. 2009. Development and validation ofagoldnanoparticle. Immunochromatographic assay (ICG) for the detection of zearalenone. Journal of Agricultural and Food Chemistry57, 4035–4041. http://dx.doi.org/10.1021/jf900075h

Singh C, Srivastava S, Ali MA, Gupta TK, Sumana G, SrivastavaA, Mathur RB,  Malhotra BD. 2013. Carboxylated multiwalled carbon nanotubes based biosensor for aflatoxin detection. Sensors and Actuators BChemical 185, 258-264. http://dx.doi.org/10.1016/j.snb.2013.04.040.

Smith JE, Sapsford KE, Tan W, Ligler FS. 2011. Optimization of antibody conjugated magnetic nanoparticles for target pre-concentration and immunoassays. Analytical Biochemistry 410, 124–132.

Solanki PR, Singh J, Rupavali B, Tiwari S, Malhotra BD. 2017. Bismuth oxide nanorods based immunosensor for mycotoxin detection. Materials Science and Engineering C 70, 564–571. http://dx.doi.org/10.1016/j.msec.2016.09.027

Tothill IE. 2001. Biosensors developments and potential applications in the agricultural diagnosis sector. Computers and Electronics in Agriculture 30,205-218. https://doi.org/10.1016/S0168-1699(00)00165-4

Tothill IE. 2011. Biosensors and nanomaterials and their application for mycotoxin determination. World Mycotoxin Journal 4, 361-374. http://dx.doi.org/10.3920/WMJ2011.1318

Turner NW, Subrahmanyam S, Piletsky SA. 2009. Analytical methods for determination of mycotoxins: a review. Analytica Chimicaacta 632, 168-180. http://dx.doi.org/10.1016/j.aca.2008.11.010

Urusov AE, Petrakova AV, Vozniak MV, Zherdev AV, Dzantiev BB. 2014. Rapid immunoenzyme assay of aflatoxin B1 using magnetic nanoparticles. Sensors14, 21843–21857. http://dx.doi.org/10.3390/s141121843

Wang Z, Duan N, Hun X, Wu S. 2010. Electrochemiluminescent aptamer biosensor for the determination of ochratoxin A at a gold-nanoparticles-modified gold electrode using N-(aminobutyl)-N-ethylisoluminol as a luminescent label. Journal of Analytical Bioanalytical Chemistry 398, 2125–2132. http://dx.doi.org/10.1007/s00216-010-4146-1

XuX, Liu X, Li Y, Ying Y.2013. A simple and rapid optical biosensor for detection of aflatoxin B1 based on competitive dispersion of gold nanorods. Biosensensors Bioelectronics 47,361–367. http://dx.doi.org/10.1016/j.bios.2013.03.048

XuX, Ying Y, Li Y.2012. A simple competitive biosensor for rapid detection of aflatoxin B1 based on aggregation of gold nanorods. Proceedings of IEEE Sensors 1-4. http://dx.doi.org/10.1109/ICSENS.2012.6411430