Evaluation of antibacterial and antioxidant activity of three plant species from Morus genus

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Research Paper 01/02/2019
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Evaluation of antibacterial and antioxidant activity of three plant species from Morus genus

Farhana Afroz Joty, Md. Mahmudul Hasan, Ratna Khatun, Md. Mutasim Billah, Md. Masum Miah, Shafi Mahmud, Md Abu Reza, Zennat Ferdousi
Int. J. Biosci.14( 2), 183-189, February 2019.
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Emergence and prevalence of antibiotic-resistant pathogenic bacteria and undesirable side effects of certain antibiotics have triggered immense interest in searching for new antimicrobial drugs of plant origin. Besides, the development of safer antioxidant, especially from plant source is also important to reduce oxidative stress related pathophysiological conditions. However, in this study, we aimed to evaluate antibacterial and antioxidant activity of the aqueous extracts of leaves of three different Morus species including M. indica (MI), M. latifolia (MLF), and M. laevigata (MLG).  Antibacterial activity was investigated against two pathogenic bacteria (E. coli and Pseudomonas) and three non-pathogenic bacteria (Acetobacter, RCA, and RVM).  The extracts were prepared at three different concentrations (0.25, 0.50, and 0.75 mg/disc) and the potency of the extracts was quantitatively assessed by the presence or absence of inhibition zone. Antioxidant potential of the three Morus species was evaluated using DPPH scavenging assay. All the three test plant possessed potent antibacterial and antioxidant capacity in a dose-dependent manner. The IC50 (dose at which 50% DPPH was scavenged) of MLF, MI, and MLG extracts were 67.21, 69.23, and 92.74 µg/mL, respectively. Among the three species, MI and MLF showed the highest antibacterial and antioxidant activity respectively. Overall, findings suggest that the three studied plant species of Morus genera are the important sources of pharmaceutical value.


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