The effect of aerobic exercise and saffron supplementation on antioxidant capacity in diabetic rats

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Research Paper 15/04/2014
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The effect of aerobic exercise and saffron supplementation on antioxidant capacity in diabetic rats

Seyed Sajjad Hosseini, Mosa Jalili, Mehrieh Panahi, Zabihollah Naghilou, Manochehr Dezhahang
Int. J. Biosci.4( 8), 1-7, April 2014.
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Abstract

The purpose of the present research was to study the effect of aerobic exercise and saffron supplementation on antioxidants capacity in diabetic rats. 50 male rats (age: 10 weeks; weight: 325±32.7 grams) were randomly divided into healthy-control (HC), diabetic-control (DC), diabetic-exercise (DE), diabetic-saffron (DS), and diabetic-saffron-exercise (DSE) groups (n = 10 per group). Except for the HC group, all the other groups induced with diabetes by injecting streptozotocin. For a period of 4 weeks, the DS and DSE groups received 30 mg/kg of daily saffron supplementation through oral gavage. The DE and DSE groups ran on the treadmill at a specific speed for 4 weeks, 4 session per week, and 30 minutes per session. After 24 hours of last session of exercise and saffron gavage, rats’ hepatic was extracted and their Total antioxidant capacity (TAC) and Glutathione (GSH) were measured. Results showed that there is a significant difference between the five groups in the levels of GSH and TAC (P = 0.000) and GSH level had the largest and lowest increase in DSE and DC respectively (P = 0.032). TAC level had the largest and lowest increase in DSE and DC respectively (P = 0.005). Thus, it can be concluded that a combination of saffron supplementation and low-intensity aerobic exercise is effective for improving the antioxidant capacity of diabetic rats.

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