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Two new antioxidant anthraquinones namely Obtusifolate A and B from Rumex obtusifolius

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Research Paper 01/04/2017
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Two new antioxidant anthraquinones namely Obtusifolate A and B from Rumex obtusifolius

Abdul Khabir, Farman Ullah Khan, Zia ul Haq, Zakir Khan, Shahidullah Khan, Shafiullah Khan
Int. J. Biosci.10( 4), 49-57, April 2017.
Certificate: IJB 2017 [Generate Certificate]
Key: Antioxidant activityObtusifolate AObtusifolate BRumex obtusifolius

Abstract

According to folk medicine Rumex obtusifolius ’s root has a prominent detoxifying result on the liver and  is used against fever, jaundice, and as an anti-anemic tonic. The roots are laxative and the leaves of this Rumex are used against hepatic, dermatological and eye problems. The diverse medicinal applications of R. obtusifolius and its genus have prompted us to investigate the constituents of the said plant.  In bio-guided isolation Two new anthraquinones namely sec-butyl 1, 8-dihydroxy-5-methyl-3-(4′-(5”methylbut-4”-enoyl)-2′-(2”oxopropyl)-6-tert-pentyl-anthraquinone-2-carboxylate (Obtusifolate A) and methyl 1, 8-dihydroxy-5-methyl-3-(2’methyl-4′-(2”methylbut-1”-enoyl)-6-tert-pentyl-anthraquinone-2-carboxylate (Obtusifolate B) were isolated from Rumex obtusifolius. Their structures were identified by chemical and modern spectroscopic techniques i.e.  1H and 13C NMR, UV, IR and mass spectrometry. Both the compounds showed excellent antioxidant activities in the DPPH radical scavenging assay. Our findings provide evidence that R. obtusifolius is a potent source of natural antioxidants, and thus justified its uses in folkloric medicines.

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