Development of a mosaic mRNA vaccine with AI-designed immunogens: A paradigm shift in vaccine science

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Review Paper 05/04/2025
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Development of a mosaic mRNA vaccine with AI-designed immunogens: A paradigm shift in vaccine science

Shafee Ur Rehman, Ahmad Habib, Azhar Shahzad, Mazhar Shahzad, Abaid Ullah, Muhammad Anas
Int. J. Biosci.26( 4), 95-104, April 2025.
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Abstract

Rapid mutations in pathogens are a significant challenge in traditional vaccines. Hence, to modify and enhance the efficiency of vaccines, mRNA vaccine technology and AI provide a transformative solution. The technology enables the researcher to design mosaic vaccines that target multiple variants or strains. Hence this review article was designed to explore the intersection of mRNA vaccine technology and AI-design immunogen design, emphasizing the potential of mosaic mRNA vaccine to enhance immunity and broaden the protection against evolving infectious diseases. Here in this study, we discuss the principle of AI design antigen optimization, the architecture of mosaic vaccine, and the critical role of lipid nanoparticles in delivery. Furthermore, we also discuss the current challenges, progress, and future direction in the development of a Mosaic mRNA Vaccine with AI-designed immunogens.

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