Prevalence of molecular markers of virulence in Candida albicans strains from Vulvovaginal infections in Abidjan, Côte d’Ivoire
Paper Details
Prevalence of molecular markers of virulence in Candida albicans strains from Vulvovaginal infections in Abidjan, Côte d’Ivoire
Abstract
Candidiasis is the term for disseminated, visceral, and mucocutaneous infections. The majority of these infections are caused by the species Candida albicans. C. albicans can infect such diverse host niches because it is supported by a variety of virulence factors and fitness attributes. These factors, particularly biofilm production, may explain treatment failures; for example, biofilm-producing strains show increased resistance to antifungal drugs and host immunity. Several genes are thought to promote biofilm formation, including those for hyphal wall protein 1 (hwp1), agglutinin-like sequence 1 (ALS1), and agglutinin-like sequence 3 (ALS3). This research aimed to detect the prevalence of virulence markers (hwp1 and ALS1) of C. albicans that were isolated from patients with vulvovaginal candidiasis. DNA extracts of C. albicans were obtained from the conserved strains. These strains were then confirmed through the application of molecular biology. The hwp1 gene was observed in 95.8% of C. albicans, and the ALS1 gene in 97.9%. The simultaneous presence of ALS1 and hwp1 genes was observed in 94.4% of C. albicans species. As the hwp1 and ALS1 genes play important roles in biofilm formation, which adds to the virulence of C. albicans, they could be targets for vulvovaginal candidiasis therapy.
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