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Acute exercise has not an anti-inflammatory property in respiratory patients

Research Paper | September 1, 2012

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Sedghi Hussein, Pourtoeiserkani Mohammad, Dooaly Hussein, Daraei Shokrabad Firooz

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Int. J. Biosci.2( 9), 102-107, September 2012

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Abstract

Proinflammatory cytokines including interleukin -1 beta (IL-1ß), a protein produced by various cells, has been involved in pathophysiology of respiratory disorders. To evaluate serum response of IL-1ß to acute exercise, seventy males with mild to moderate asthma Aged 35 to 45 years participated in this study and its serum levels were measured before and immediately after a single bout cycling test. Student’s t-tests for paired samples were performed to determine significance of changes in variables by exercise test in asthma subjects. Significance was accepted at P < 0.05. No significant differences were found in this cytokine by cycling exercise with compared to baseline. Based on this data, we can say on short-time exercise has not an anti-inflammatory properties in asthma patients.

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Acute exercise has not an anti-inflammatory property in respiratory patients

Borish L, Mascali JJ, Dishuck J, Beam WR, Martin RJ, Rosenwasser LJ. 1992. Detection of alveolar macrophage-derived IL-1 beta in asthma. Inhibition with corticosteroids. J Immunol 149, 3078–3082.

Chung KF and Barnes PJ. 1999. Cytokines in asthma. Thorax 54, 825-57.

Dinarello CA. 1998. Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist. Int Rev Immunol 16, 457–499.

Eizadi M, Zand AR, Faraji GR, Parsian H. 2011. Serum interleukin-1beta and lipid profile responses to aerobic training in obese men. Journal of Biodiversity and Environmental Sciences 2(6), 60-66.

Fanelli A, Cabral ALB, Neder JA, Martins MA, Carvalho CRF. 2007. Exercise training on disease control and quality of life in asthmatics children. Med Sci Sports Exerc 39, 1481–1486.

Gomez-Merino D, Drogou C, Guezennec CY, Chennaoui M. 2007. Effects of chronic exercise on cytokine production in white adipose tissue and skeletal muscle of rats. Cytokine 40(1), 23-9.

Hakonarson H, Halapi E, Whelan R, Gulcher J, Stefansson K, Grunstein MM. 2001. Association between IL-beta/TNFalpha-induced glucocorticoid-sensitive changes in multiple gene expression and altered responsiveness in airway smooth muscle. Am J Respir Cell Mol Biol 25, 761– 771.

Hakonarson H, Maskeri N, Carter C, Chuang S, Grunstein MM. 1999. Autocrine interaction between IL-5 and IL-1beta mediates altered responsiveness of atopic asthmatic sensitized airway smooth muscle. J Clin Invest 104, 657–667.

Hakonarson H, Maskeri N, Carter C, Chuang S, Grunstein MM. 1999. Autocrine interaction between IL-5 and IL-1beta mediates altered responsiveness of atopic asthmatic sensitized airway smooth muscle. J Clin Invest 104, 657–667.

Hakonarson H, Whelan R, Leiter J. 2002. T lymphocytemediated changes in airway smooth muscle responsiveness are attributed to induced autocrine release and actions of IL-5 and IL-1beta. J Allergy Clin Immunol 110, 624–633.

Jurimae J, Jurimae T. 2005. Leptin responses to short term exercise in college level male rowers. Br J Sports Med 39, 6–9.

Jurimae J, Hofmann P, Jurimae T. 2006. Plasma adiponectin response to sculling exercise at individual anaerobic threshold in college level male rowers. Int J Sports Med 27, 272–7.

Kunkel SL, Chensue SW, Colletti C, Standiford T, Luckacs N and Strieter RM. 2000. Cytokine networks and leukocyte recruitment In: Cytokines in Pulmonary Disease: Infection and Inflamma-tion 1, 19-35.

Maedler K, Dharmadhikari G, Schumann DM, Størling J. 2009. Interleukin-1 beta targeted therapy for type 2 diabetes. Expert Opin Biol Ther 9(9), 1177-88.

Mahajan S, Anita A. 2006. Role of Cytokines in Pathophysiology of Asthma. Iranian Journal of Pharmocology & Therapeutics 5(1), 1-14.

Mullis R, Campbell IT, Wearden AJ, Morriss RK, Pearson DJ. 1999. Prediction of peak oxygen uptake in chronic fatigue syndrome. British Journal of Sports Medicine 33(5), 352-6.

Orenstein DM. 1996. Asthma and sports. In: Bar-Or O, editor. The child and the adolescent athlete. London: Blackwell 1, 433–454.

Pujol JL, Cosso B, Daures JP, Clot J, Michel FB, Godard P. 1990. Interleukin-1 release by alveolar macrophages in asthmatic patients and healthy subjects. Int Arch Allergy Appl Immunol 91, 207–210.

Ram FS, Robinson SM, Black PN, Picot J. 2005. Physical training for asthma. Cochrane Database Syst Rev 4, CD001116.

Shore SA, Moore PE. 2002. Effects of cytokines on contractile and dilator responses of airway smooth muscle. Clin Exp Pharmacol Physiol 29, 859–866.

Takizawa H. 1998. Cytokines/chemokines and adhesion molecules in local inflammatory responses of the lung. Drug News Perspect 11(10), 611-9.

Whelan R, Kim C, Chen M, Leiter J, Grunstein MM, Hakonarson H. 2004. Role and regulation of interleukin-1 molecules in pro-asthmatic sensitised airway smooth muscle. Eur Respir J 24(4), 559-67.

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