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Antioxidant and antiproliferative activity of phytoconstituents identified from Sargassum binderi seaweed extracts cultivated in Bangladesh

By: A.K.M. Asaduzzaman, Imtiaj Hasan, M. Habibur Rahman, Abu Rayhan Mohammad Tareq

Key Words: Antioxidant, Anticancer, Cytotoxicity, Ehrlich ascites carcinoma cells, Sargassum binderi.

Int. J. Biosci. 16(3), 481-494, March 2020.

DOI: http://dx.doi.org/10.12692/ijb/16.3.481-494

Certification: ijb 2020 0064 [Generate Certificate]

Abstract

In the present study, seaweed Sargassum binderi was extracted by the solvent ethanol and methanol. As phytoconstituents of both extracts were analyzed by gas chromatography-mass spectrometry (GC-MS), eighteen and nineteen compounds have been found from the ethanolic extract and methanolic extract, respectively. 1,2-Benzenedicarboxylic acid, diisooctyl esters was found in higher amounts and Pentadecanoic acid, 14-methyl-, methyl ester was the other major compounds present in both extracts. Total phenolic and flavonoid compounds were found to be as 11.890 mg gallic acid equivalent (GAE)/g and 269.542 mg catechin (CE)/g from ethanolic extract and 11.495 mg GAE/g and 266.936 mg CE/g from the methanolic extract. Good percentages of scavenging activity of DPPH, ABTS, total antioxidant and ferric reducing power have been observed in both extracts. 88.33% and 87.27% cell growth inhibition was observed in vitro at 176 µg/ml, respectively. Both S. binderi extracts showed mild toxicity against brine shrimp nauplii with LC50 values of 106.66 µg/ml and 125.82 µg/ml, respectively. Therefore we can say the ethanolic and methanolic extracts of S. binderi are a promising source of new molecules with possible applications as antioxidants and in cancer therapeutics.

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Antioxidant and antiproliferative activity of phytoconstituents identified from Sargassum binderi seaweed extracts cultivated in Bangladesh

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A.K.M. Asaduzzaman, Imtiaj Hasan, M. Habibur Rahman, Abu Rayhan Mohammad Tareq.
Antioxidant and antiproliferative activity of phytoconstituents identified from Sargassum binderi seaweed extracts cultivated in Bangladesh.
Int. J. Biosci. 16(3), 481-494, March 2020.
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